[图书][B] Discrete-event modeling and simulation: a practitioner's approach
GA Wainer - 2017 - taylorfrancis.com
Complex artificial dynamic systems require advanced modeling techniques that can
accommodate their asynchronous, concurrent, and highly non-linear nature. Discrete Event …
accommodate their asynchronous, concurrent, and highly non-linear nature. Discrete Event …
Physiologically based synthetic models of hepatic disposition
CA Hunt, GEP Ropella, L Yan, DY Hung… - … of pharmacokinetics and …, 2006 - Springer
Current physiologically based pharmacokinetic (PBPK) models are inductive. We present an
additional, different approach that is based on the synthetic rather than the inductive …
additional, different approach that is based on the synthetic rather than the inductive …
Discrete event modelling and simulation in systems biology
Abstract With Systems Biology, a promising new application area for modelling and
simulation emerges. Today's biologists are facing huge amounts of data delivered at …
simulation emerges. Today's biologists are facing huge amounts of data delivered at …
Prediction of in vitro hepatic biliary excretion using stochastic agent-based modeling and fuzzy clustering
S Sheikh-Bahaei, CA Hunt - Proceedings of the 2006 Winter …, 2006 - ieeexplore.ieee.org
We present a method for estimating (predicting) parameter values for an agent-based model
of in silico hepatocytes (ISH). The method enables the ISH to interact with simulated drugs to …
of in silico hepatocytes (ISH). The method enables the ISH to interact with simulated drugs to …
[PDF][PDF] Methodological considerations of heuristic modeling of biological systems
We present the basics of a modeling method, FURM (Functional Unit Representation
Method) that attempts to address a fundamental difference in the practice of biological …
Method) that attempts to address a fundamental difference in the practice of biological …
[PDF][PDF] Agent-based simulation of in vitro hepatic drug metabolism: in silico hepatic intrinsic clearance
S Sheikh-Bahaei, GEP Ropella… - … (San Diego, CA, Apr 2-8) …, 2005 - researchgate.net
Agent-Based Simulation of In Vitro Hepatic Drug Metabolism: In Silico Hepatic Intrinsic
Clearance Page 1 PREPRINT Paper accepted: 01/07/05 – 1 – 2005 Spring Simulation …
Clearance Page 1 PREPRINT Paper accepted: 01/07/05 – 1 – 2005 Spring Simulation …
[PDF][PDF] Advanced DEVS models with application to biomedicine
G Wainer, S Jafer, B Al-Aubidy… - Artificial …, 2007 - cell-devs-02.sce.carleton.ca
Simulation is becoming increasingly important in the analysis and design of complex
systems such as those involving biological processes. The complexity of these systems …
systems such as those involving biological processes. The complexity of these systems …
[PDF][PDF] In silico hepatocyte: agent-based modeling of the biliary excretion of drugs in vitro
We have used a stochastic agent directed, cellular automatabased synthetic method to
instantiate, test, and partially validate simulation models of cultured primary hepatocytes (the …
instantiate, test, and partially validate simulation models of cultured primary hepatocytes (the …
DEVS modelling and simulation of the cellular metabolism by mitochondria
G Wainer, R Djafarzadeh - Molecular Simulation, 2010 - Taylor & Francis
We present a method for modelling and simulating metabolic pathways in the cells (namely,
the glycolysis and Krebs' cycle), using the discrete event system specification (DEVS) …
the glycolysis and Krebs' cycle), using the discrete event system specification (DEVS) …
[PDF][PDF] PISL: A large-scale in silico experimental framework for agent-directed physiological models
S Park, CA Hunt, GEP Ropella - … '05), The Society for Modeling and …, 2005 - researchgate.net
We present in silico, physiologically-based rat liver models that are designed for large-scale
and high-performance experimentation and analysis. We refer to the framework used as the …
and high-performance experimentation and analysis. We refer to the framework used as the …