Cirrhosis-associated immune dysfunction

A Albillos, R Martin-Mateos, S Van der Merwe… - Nature Reviews …, 2022 - nature.com
The term cirrhosis-associated immune dysfunction (CAID) comprises the distinctive
spectrum of immune alterations associated with the course of end-stage liver disease …

[HTML][HTML] The systemic inflammation hypothesis: towards a new paradigm of acute decompensation and multiorgan failure in cirrhosis

V Arroyo, P Angeli, R Moreau, R Jalan, J Clària… - Journal of …, 2021 - Elsevier
Acute decompensation (AD) of cirrhosis is defined by the development of ascites, hepatic
encephalopathy (HE) and/or variceal bleeding. Ascites is traditionally attributed to …

Advances in the understanding and treatment of sepsis-induced immunosuppression

F Venet, G Monneret - Nature Reviews Nephrology, 2018 - nature.com
Sepsis is defined as a life-threatening organ dysfunction that is caused by a dysregulated
host response to infection. Sepsis can induce acute kidney injury and multiple organ failures …

[PDF][PDF] Liver macrophages: old dogmas and new insights

A Guillot, F Tacke - Hepatology communications, 2019 - Wiley Online Library
Inflammation is a hallmark of virtually all liver diseases, such as liver cancer, fibrosis,
nonalcoholic steatohepatitis, alcoholic liver disease, and cholangiopathies. Liver …

Albumin in decompensated cirrhosis: new concepts and perspectives

M Bernardi, P Angeli, J Claria, R Moreau, P Gines… - Gut, 2020 - gut.bmj.com
The pathophysiological background of decompensated cirrhosis is characterised by a
systemic proinflammatory and pro-oxidant milieu that plays a major role in the development …

[HTML][HTML] Acute-on-chronic liver failure: definitions, pathophysiology and principles of treatment

G Zaccherini, E Weiss, R Moreau - JHEP Reports, 2021 - Elsevier
The term acute-on-chronic liver failure (ACLF) defines an abrupt and life-threatening
worsening of clinical conditions in patients with cirrhosis or chronic liver disease. In recent …

The role of monocytes and macrophages in acute and acute-on-chronic liver failure

E Triantafyllou, KJ Woollard, MJW McPhail… - Frontiers in …, 2018 - frontiersin.org
Acute and acute-on-chronic liver failure (ALF and ACLF), though distinct clinical entities, are
considered syndromes of innate immune dysfunction. Patients with ALF and ACLF display …

Innate immune cells in cirrhosis

C Bernsmeier, S van Der Merwe, A Périanin - Journal of hepatology, 2020 - Elsevier
Cirrhosis is a multisystemic disease wherein inflammatory responses originating from
advanced liver disease and its sequelae affect distant compartments. Patients with cirrhosis …

Acute-on-chronic liver failure: Far to go—A review

J Luo, J Li, P Li, X Liang, HM Hassan, R Moreau, J Li - Critical Care, 2023 - Springer
Acute-on-chronic liver failure (ACLF) has been recognized as a severe clinical syndrome
based on the acute deterioration of chronic liver disease and is characterized by organ …

Leukocytes, systemic inflammation and immunopathology in acute-on-chronic liver failure

M Casulleras, IW Zhang, C López-Vicario, J Clària - Cells, 2020 - mdpi.com
Acute-on-chronic liver failure (ACLF) is a complex syndrome that develops in patients with
cirrhosis and is characterized by acute decompensation, organ failure (s) and high short …