In this review the current state‐of‐the‐art of S‐adenosylmethionine (SAM)‐dependent
methyltransferases and SAM are evaluated. Their structural classification and diversity is …

Covering: 1999 to 2014 Type 1, α/β hydrolase-like thioesterase (TE) domains are essential
offloading enzymes, releasing covalently bound products from fatty acid, polyketide, and non …

The ability to site-selectively modify equivalent functional groups in a molecule has the
potential to streamline syntheses and increase product yields by lowering step counts …

As a robust, fast growing and genetically tractable organism, the budding yeast
Saccharomyces cerevisiae is one of the most widely used hosts in biotechnology. Its …

Resorcylic acid lactones (RALs) are fungal polyketides that consist of a β-resorcylic acid
residue (2, 4-dihydroxybenzoic acid) embedded in a macrolactone ring. RALs exhibit a …

Jasmonic acid (JA) and its derivatives called jasmonates (JAs) are lipid-derived signalling
molecules that are produced by plants and certain fungi. Beside this function, JAs have a …

Covering: 1999 up to 2021 Fungal polyketides encompass a range of structurally diverse
molecules with a wide variety of biological activities. The giant multifunctional enzymes that …

Benzenediol lactones are a structurally variable family of fungal polyketide metabolites
possessing a macrolide core structure fused into a resorcinol aromatic ring. These …

Saccharomyces cerevisiae has been extensively used as a convenient synthetic biology
chassis to reconstitute fungal polyketide biosynthetic pathways. Despite progress in …

Combinatorial biosynthesis aspires to exploit the promiscuity of microbial anabolic pathways
to engineer the synthesis of new chemical entities. Fungal benzenediol lactone (BDL) …