The evolutionary origins of neurons remain unknown. Although recent genome data of
extant early-branching animals have shown that neural genes existed in the common …

Mitochondria play a pivotal role in the generation of signals coupling metabolism with
neurotransmitter release, but a role for mitochondrial-produced ROS in regulating …

Rab GTPases are a class of small GTP-binding proteins, play crucial roles in the membrane
transport machinery with in eukaryotic cells. They dynamically regulate the precise targeting …

Chemogenetic and optogenetic tools have transformed the field of neuroscience by
facilitating the examination and manipulation of existing circuits. Yet, the field lacks tools that …

Fast axonal transport is crucial for neuronal function and is driven by kinesins and
cytoplasmic dynein. Here, we investigated the role of kinesin-1 in dense core vesicle (DCV) …

Some Parkinson's disease (PD)-causative/risk genes, including the PD-associated kinase
leucine-rich repeat kinase 2 (LRRK2), are involved in membrane dynamics. Although …

Fast axonal transport of neuropeptide-containing dense core vesicles (DCVs),
endolysosomal organelles, and presynaptic components is critical for maintaining neuronal …

Nematode parasites of humans, livestock and crops dramatically impact human health and
welfare. Alarmingly, parasitic nematodes of animals have rapidly evolved resistance to …

Neural circuit synaptic connectivities (the connectome) provide the anatomical foundation for
our understanding of nematode nervous system function. However, other nonsynaptic routes …

Injured axons must regenerate to restore nervous system function, and regeneration is
regulated in part by external factors from non-neuronal tissues. Many of these extrinsic …