The vertebrate motor system is equipped with a number of neuronal networks that underlie
different patterns of behaviour, from simple protective reflexes to complex movements. The …

Over the past 40 years, much has been learned about the role of serotonin in spinal cord
reflex modulation and locomotor pattern generation. This review presents an historical …

We examined the modulation of persistent inward currents (PICs) by serotonin (5-HT) in
spinal motoneurons of normal and chronic spinal rats. PICs are composed of both a TTX …

Highlights•5-HT promotes locomotion and the excitability of motoneurons.•The effects
induced by exogenous and synaptically released 5-HT are different.•High intensity release …

Ionotropic inputs to motoneurones have the capacity to depolarise and hyperpolarise the
motoneurone, whereas neuromodulatory inputs control the state of excitability of the …

Vertebrate locomotion must be adaptable in light of changing environmental, organismal,
and developmental demands. Much of the underlying flexibility in the output of central …

In the present study, concurrent treatment with robotic step training and a serotonin agonist,
quipazine, generated significant recovery of locomotor function in complete spinal cord …

Serotonin (5-HT) is one of the main transmitters in the nervous system. Serotonergic
neurons in the raphe nuclei in the brainstem innervate most parts of the central nervous …

Among the advantages offered by the lamprey brainstem and spinal cord for studies of the
structure and function of the nervous system is the unique identifiability of several pairs of …

Recently, it has been shown that bath-applied 5-HT can elicit fictive locomotion from
perinatal mouse preparations. Since 5-HT acts on multiple receptor subtypes, the focus of …