During severe inflammatory and infectious diseases, various mediators modulate the
equilibrium of vascular tone, inflammation, coagulation and thrombosis. This Review …

Evolving information has identified disease mechanisms and dysregulation of host biology
that might be targeted therapeutically in coronavirus disease 2019 (COVID-19). Thrombosis …

The development of extracorporeal life support technology has added a new dimension to
the care of critically ill patients who fail conventional treatment options. Extracorporeal …

Peptides have traditionally been perceived as poor drug candidates due to unfavorable
characteristics mainly regarding their pharmacokinetic behavior, including plasma stability …

Cyclotides are plant-derived peptides with complex structures shaped by their head-to-tail
cyclic backbone and cystine knot core. These structural features underpin the native …

It is a challenge to degrade sulfated polysaccharides without stripping sulfate groups. In the
present study, a photocatalytic method was applied to degrade fucoidan, a sulfated …

Artificial lung membrane as extracorporeal blood-gas barriers could execute similar
functions as human alveoli, whereby accomplish blood gas exchange process, providing …

Blood contact with high surface area medical devices, such as dialysis and extracorporeal
life support (ECLS), induces rapid surface coagulation. Systemic anticoagulation, such as …

Introduction: Blood coagulation factor XII (FXII) is an emerging and potentially safe drug
target, which dysregulation is associated with thrombosis, hereditary angioedema, and …

Most SARS-CoV-2 infected patients experience influenza-like symptoms of low or moderate
severity. But, already in 2020 early during the pandemic it became obvious that many …