Molecular mechanisms and physiological functions of mitophagy

M Onishi, K Yamano, M Sato, N Matsuda… - The EMBO …, 2021 - embopress.org
Degradation of mitochondria via a selective form of autophagy, named mitophagy, is a
fundamental mechanism conserved from yeast to humans that regulates mitochondrial …

Mitochondria in skin health, aging, and disease

A Sreedhar, L Aguilera-Aguirre, KK Singh - Cell death & disease, 2020 - nature.com
The skin is a high turnover organ, and its constant renewal depends on the rapid
proliferation of its progenitor cells. The energy requirement for these metabolically active …

Structural basis and regulation of the reductive stress response

AG Manford, EL Mena, KY Shih, CL Gee, R McMinimy… - Cell, 2021 - cell.com
Although oxidative phosphorylation is best known for producing ATP, it also yields reactive
oxygen species (ROS) as invariant byproducts. Depletion of ROS below their physiological …

Mitochondrial dynamics: fission and fusion in fate determination of mesenchymal stem cells

L Ren, X Chen, X Chen, J Li, B Cheng… - Frontiers in cell and …, 2020 - frontiersin.org
Mesenchymal stem cells (MSCs) are pivotal to tissue homeostasis, repair, and regeneration
due to their potential for self-renewal, multilineage differentiation, and immune modulation …

Mitochondria can cross cell boundaries: An overview of the biological relevance, pathophysiological implications and therapeutic perspectives of intercellular …

D Valenti, RA Vacca, L Moro, A Atlante - International journal of molecular …, 2021 - mdpi.com
Mitochondria are complex intracellular organelles traditionally identified as the
powerhouses of eukaryotic cells due to their central role in bioenergetic metabolism. In …

Mitochondrial dynamics in stem cells and differentiation

BJ Seo, SH Yoon, JT Do - International journal of molecular sciences, 2018 - mdpi.com
Mitochondria are highly dynamic organelles that continuously change their shape. Their
main function is adenosine triphosphate (ATP) production; however, they are additionally …

Mitochondria in cancer stem cells: Achilles heel or hard armor

X Zheng, J Chen, Y Sun, T Chen, J Wang, S Yu - Trends in Cell Biology, 2023 - cell.com
Previous studies have shown that mitochondria play core roles in not only cancer stem cell
(CSC) metabolism but also the regulation of CSC stemness maintenance and differentiation …

Mitochondria—hubs for regulating cellular biochemistry: emerging concepts and networks

AJ Anderson, TD Jackson, DA Stroud… - Open …, 2019 - royalsocietypublishing.org
Mitochondria are iconic structures in biochemistry and cell biology, traditionally referred to
as the powerhouse of the cell due to a central role in energy production. However, modern …

Mitochondrial plasticity in cell fate regulation

A Bahat, A Gross - Journal of Biological Chemistry, 2019 - ASBMB
Mitochondria are considered highly plastic organelles. This plasticity enables the
mitochondria to undergo morphological and functional changes in response to cellular …

Plin2-mediated lipid droplet mobilization accelerates exit from pluripotency by lipidomic remodeling and histone acetylation

Y Wu, K Chen, L Li, Z Hao, T Wang, Y Liu… - Cell Death & …, 2022 - nature.com
Metabolic switch is critical for cell fate determination through metabolic functions, epigenetic
modifications, and gene expression. However, the mechanisms underlying these alterations …