Leveraging self-assembled nanobiomaterials for improved cancer immunotherapy

MP Vincent, JO Navidzadeh, S Bobbala, EA Scott - Cancer Cell, 2022 - cell.com
Nanomaterials and targeted drug delivery vehicles improve the therapeutic index of drugs
and permit greater control over their pharmacokinetics, biodistribution, and bioavailability …

Use of stimulatory responsive soft nanoparticles for intracellular drug delivery

KA Hughes, B Misra, M Maghareh, S Bobbala - Nano Research, 2023 - Springer
Drug delivery has made tremendous advances in the last decade. Targeted therapies are
increasingly common, with intracellular delivery highly impactful and sought after …

Surface chemistry-mediated modulation of adsorbed albumin folding state specifies nanocarrier clearance by distinct macrophage subsets

MP Vincent, S Bobbala, NB Karabin, M Frey… - Nature …, 2021 - nature.com
Controlling nanocarrier interactions with the immune system requires a thorough
understanding of the surface properties that modulate protein adsorption in biological fluids …

Tuneable time delay in the burst release from oxidation‐sensitive polymersomes made by PISA

FH Sobotta, MT Kuchenbrod… - Angewandte Chemie …, 2021 - Wiley Online Library
Reactive polymersomes represent a versatile artificial cargo carrier system that can facilitate
an immediate release in response to a specific stimulus. The herein presented oxidation …

Stimuli-controllable iron oxide nanoparticle assemblies: Design, manipulation and bio-applications

LE Low, HP Lim, YS Ong, SP Siva, CS Sia… - Journal of Controlled …, 2022 - Elsevier
Despite its wide establishment over the years, iron oxide nanoparticle (IONP) still draws
extensive interest in the biomedical fields due to its biocompatibility, biodegradability …

Recent progress in polymer cubosomes and hexosomes

H Chen, MH Li - Macromolecular Rapid Communications, 2021 - Wiley Online Library
Polymer cubosomes and hexosomes are polymer colloids with inverted lyotropic liquid
crystal phases as internal structures. They are composed of regular networks of water‐filled …

Bicontinuous Nanoparticles from Spontaneous Self-Assembly of Block Copolymer Prodrug in Aqueous Medium for Potential Cancer Therapy

J Pal, P Samanta, A Khan, R Maity, AI Mallick… - ACS Macro …, 2024 - ACS Publications
Despite having several advantages, bicontinuously structured polymeric nanoparticles
(BSPNPs) are far less explored in the field of controlled drug delivery owing to the …

The combination of morphology and surface chemistry defines the immunological identity of nanocarriers in human blood

MP Vincent, NB Karabin, SD Allen… - Advanced …, 2021 - Wiley Online Library
Upon exposure to blood, a corona of proteins adsorbs to nanocarrier surfaces to confer a
biological identity that interfaces with the immune system. While the nanocarrier surface …

Synthesis and applications of polymer cubosomes and hexosomes

CF Grandes Reyes, S Ha, KT Kim - Journal of Polymer Science, 2023 - Wiley Online Library
The synthesis and use of polymer cubosomes have received significant attention in recent
years. Polymer cubosomes are highly stable colloidal particles with triply periodic minimal …

Targeted delivery of cell softening micelles to Schlemm's canal endothelial cells for treatment of glaucoma

T Stack, M Vincent, A Vahabikashi, G Li, KM Perkumas… - Small, 2020 - Wiley Online Library
Increased stiffness of the Schlemm's canal (SC) endothelium in the aqueous humor outflow
pathways has been associated with elevated intraocular pressure (IOP) in glaucoma. Novel …