Abstract Reduction-oxidation factor 1-apurinic/apyrimidinic endonuclease (Ref-1/APE1) is a
critical node in tumor cells, both as a redox regulator of transcription factor activation and as …

Fanconi anemia (FA) is a recessive genetic disorder caused by biallelic mutations in at least
one of 22 FA genes. Beyond its pathological presentation of bone marrow failure and …

Two genes are synthetic lethal if mutations in both genes result in impaired cell viability,
while mutation of either gene does not affect the cell survival. The potential usage of …

Synthetic lethality (SL) occurs between two genes when the inactivation of either gene alone
has no effect on cell survival but the inactivation of both genes results in cell death. SL …

In recent years, there has been a surge in the innovative modification and application of the
viral vector-based gene therapy field. Significant and consistent improvements in the …

Agents that induce DNA damage can cure some cancers. However, the side effects of
chemotherapy are severe because of the indiscriminate action of DNA-damaging agents on …

Breast cancer is a persistent threat to women worldwide. A large proportion of breast
cancers are dependent on the estrogen receptor α (ERα) for tumor progression. Therefore …

Chemotherapy agents can cause serious adverse effects by attacking both cancer tissues
and normal tissues. Therefore, we proposed a synthetic lethality (SL) concept-based …

E3 ubiquitin ligases (E3s) play a critical role in molecular and cellular mechanisms.
However, a large number of E3-substrate interactions (ESIs) remain unrevealed. Here, we …

Functional buffering that ensures biological robustness is critical for maintaining tissue
homeostasis, organismal survival, and evolution of novelty. However, the mechanism …