The value of antimicrobial peptides in the age of resistance

M Magana, M Pushpanathan, AL Santos… - The lancet infectious …, 2020 - thelancet.com
Accelerating growth and global expansion of antimicrobial resistance has deepened the
need for discovery of novel antimicrobial agents. Antimicrobial peptides have clear …

Antimicrobial peptides: An alternative to traditional antibiotics

S Ji, F An, T Zhang, M Lou, J Guo, K Liu, Y Zhu… - European Journal of …, 2024 - Elsevier
As antibiotic-resistant bacteria and genes continue to emerge, the identification of effective
alternatives to traditional antibiotics has become a pressing issue. Antimicrobial peptides …

Identification of antimicrobial peptides from the human gut microbiome using deep learning

Y Ma, Z Guo, B Xia, Y Zhang, X Liu, Y Yu, N Tang… - Nature …, 2022 - nature.com
The human gut microbiome encodes a large variety of antimicrobial peptides (AMPs), but
the short lengths of AMPs pose a challenge for computational prediction. Here we combined …

sAMPpred-GAT: prediction of antimicrobial peptide by graph attention network and predicted peptide structure

K Yan, H Lv, Y Guo, W Peng, B Liu - Bioinformatics, 2023 - academic.oup.com
Abstract Motivation Antimicrobial peptides (AMPs) are essential components of therapeutic
peptides for innate immunity. Researchers have developed several computational methods …

Alternative therapeutic strategies to treat antibiotic-resistant pathogens

CR MacNair, ST Rutherford, MW Tan - Nature Reviews Microbiology, 2024 - nature.com
Resistance threatens to render antibiotics—which are essential for modern medicine—
ineffective, thus posing a threat to human health. The discovery of novel classes of …

Molecular de-extinction of ancient antimicrobial peptides enabled by machine learning

JRMA Maasch, MDT Torres, MCR Melo… - Cell Host & Microbe, 2023 - cell.com
Molecular de-extinction could offer avenues for drug discovery by reintroducing bioactive
molecules that are no longer encoded by extant organisms. To prospect for antimicrobial …

Deep-AmPEP30: improve short antimicrobial peptides prediction with deep learning

J Yan, P Bhadra, A Li, P Sethiya, L Qin, HK Tai… - … Therapy-Nucleic Acids, 2020 - cell.com
Antimicrobial peptides (AMPs) are a valuable source of antimicrobial agents and a potential
solution to the multi-drug resistance problem. In particular, short-length AMPs have been …

Computer-aided design of antimicrobial peptides: are we generating effective drug candidates?

MH Cardoso, RQ Orozco, SB Rezende… - Frontiers in …, 2020 - frontiersin.org
Antimicrobial peptides (AMPs), especially antibacterial peptides, have been widely
investigated as potential alternatives to antibiotic-based therapies. Indeed, naturally …

Large-scale analyses of human microbiomes reveal thousands of small, novel genes

H Sberro, BJ Fremin, S Zlitni, F Edfors, N Greenfield… - Cell, 2019 - cell.com
Small proteins are traditionally overlooked due to computational and experimental
difficulties in detecting them. To systematically identify small proteins, we carried out a …

Comprehensive assessment of machine learning-based methods for predicting antimicrobial peptides

J Xu, F Li, A Leier, D Xiang, HH Shen… - Briefings in …, 2021 - academic.oup.com
Antimicrobial peptides (AMPs) are a unique and diverse group of molecules that play a
crucial role in a myriad of biological processes and cellular functions. AMP-related studies …