OP-EHEA191011_online 2313..2340 Page 1 Low-density lipoproteins cause atherosclerotic
cardiovascular disease: pathophysiological, genetic, and therapeutic insights: a consensus …

Significance: The release of myeloperoxidase (MPO) by activated leukocytes is critical in
innate immune responses. MPO produces hypochlorous acid (HOCl) and other strong …

The heme peroxidase family generates a battery of oxidants both for synthetic purposes, and
in the innate immune defence against pathogens. Myeloperoxidase (MPO) is the most …

Hypercholesterolaemia leads to cholesterol accumulation in macrophages and other
immune cells, which promotes inflammatory responses, including augmentation of Toll-like …

High-density lipoproteins (HDLs) protect against atherosclerosis by removing excess
cholesterol from macrophages through the ATP-binding cassette transporter A1 (ABCA1) …

The cholesterol contained within HDL is inversely associated with risk of coronary heart
disease and is a key component of predicting cardiovascular risk. However, despite its …

The cardiovascular system is subject to hyperlipidaemic, inflammatory, and pro-oxidant
stressors. Over time, these factors drive prevalent chronic diseases, of which atherosclerosis …

Several prospective epidemiological studies have shown that there is a clear inverse
relationship between serum high-density lipoprotein-cholesterol (HDL-C) concentrations …

Apolipoprotein AI (ApoA-I), the major protein component of high-density lipoproteins (HDL)
is a multifunctional protein, involved in cholesterol traffic and inflammatory and immune …

Since the discovery in the 1970s that plasma levels of high-density lipoprotein cholesterol
(HDL-C) are inversely associated with cardiovascular outcome, it has been postulated that …