The dynamic brain N-glycome

TS Klarić, G Lauc - Glycoconjugate journal, 2022 - Springer
The attachment of carbohydrates to other macromolecules, such as proteins or lipids, is an
important regulatory mechanism termed glycosylation. One subtype of protein glycosylation …

Mammalian brain glycoproteins exhibit diminished glycan complexity compared to other tissues

SE Williams, M Noel, S Lehoux, M Cetinbas… - Nature …, 2022 - nature.com
Glycosylation is essential to brain development and function, but prior studies have often
been limited to a single analytical technique and excluded region-and sex-specific analyses …

Spatial and temporal diversity of glycome expression in mammalian brain

J Lee, S Ha, M Kim, SW Kim, J Yun… - Proceedings of the …, 2020 - National Acad Sciences
Mammalian brain glycome remains a relatively poorly understood area compared to other
large-scale “omics” studies, such as genomics and transcriptomics due to the inherent …

Analysis of carbohydrates and glycoconjugates by matrix‐assisted laser desorption/ionization mass spectrometry: an update for 2015–2016

DJ Harvey - Mass Spectrometry Reviews, 2021 - Wiley Online Library
This review is the ninth update of the original article published in 1999 on the application of
matrix‐assisted laser desorption/ionization (MALDI) mass spectrometry to the analysis of …

GolpHCat (TMEM87A), a unique voltage-dependent cation channel in Golgi apparatus, contributes to Golgi-pH maintenance and hippocampus-dependent memory

H Kang, A Han, A Zhang, H Jeong, W Koh… - Nature …, 2024 - nature.com
Impaired ion channels regulating Golgi pH lead to structural alterations in the Golgi
apparatus, such as fragmentation, which is found, along with cognitive impairment, in …

[HTML][HTML] N-glycoproteomics of brain synapses and synaptic vesicles

MM Bradberry, TM Peters-Clarke, E Shishkova… - Cell reports, 2023 - cell.com
At mammalian neuronal synapses, synaptic vesicle (SV) glycoproteins are essential for
robust neurotransmission. Asparagine (N)-linked glycosylation is required for delivery of the …

Brain somatic mutations in SLC35A2 cause intractable epilepsy with aberrant N-glycosylation

NS Sim, Y Seo, JS Lim, WK Kim, H Son… - Neurology …, 2018 - AAN Enterprises
Objective To identify whether somatic mutations in SLC35A2 alter N-glycan structures in
human brain tissues and cause nonlesional focal epilepsy (NLFE) or mild malformation of …

Enhanced Detection of Charged N-Glycans in the Brain by Infrared Matrix-Assisted Laser Desorption Electrospray Ionization Mass Spectrometric Imaging

J Samal, TV Palomino, J Chen, DC Muddiman… - Analytical …, 2023 - ACS Publications
N-linked glycosylation represents a structurally diverse, complex, co-and posttranslational
protein modification that bridges metabolism and cellular signaling. Consequently, aberrant …

Mouse tissue glycome atlas 2022 highlights inter-organ variation in major N-glycan profiles

M Otaki, N Hirane, Y Natsume-Kitatani… - Scientific reports, 2022 - nature.com
This study presents “mouse tissue glycome atlas” representing the profiles of major N-
glycans of mouse glycoproteins that may define their essential functions in the surface …

[HTML][HTML] N-Glycan profiling of lung adenocarcinoma in patients at different stages of disease

E Lattová, J Skřičková, J Hausnerová, L Frola, L Křen… - Modern Pathology, 2020 - Elsevier
Lung adenocarcinoma (LAC) is the most common form of lung cancer that increases in non-
smokers at younger age. Altered protein glycosylation is one of the hallmarks of malignancy …