Amino acid metabolism in immune cells: essential regulators of the effector functions, and promising opportunities to enhance cancer immunotherapy
L Yang, Z Chu, M Liu, Q Zou, J Li, Q Liu… - Journal of hematology & …, 2023 - Springer
Amino acids are basic nutrients for immune cells during organ development, tissue
homeostasis, and the immune response. Regarding metabolic reprogramming in the tumor …
homeostasis, and the immune response. Regarding metabolic reprogramming in the tumor …
Regulation of cancer cell metabolism: oncogenic MYC in the driver's seat
Y Dong, R Tu, H Liu, G Qing - Signal transduction and targeted therapy, 2020 - nature.com
Cancer cells must rewire cellular metabolism to satisfy the demands of unbridled growth and
proliferation. As such, most human cancers differ from normal counterpart tissues by a …
proliferation. As such, most human cancers differ from normal counterpart tissues by a …
Improved prime editors enable pathogenic allele correction and cancer modelling in adult mice
Prime editors (PEs) mediate genome modification without utilizing double-stranded DNA
breaks or exogenous donor DNA as a template. PEs facilitate nucleotide substitutions or …
breaks or exogenous donor DNA as a template. PEs facilitate nucleotide substitutions or …
Amino acid transporters revisited: New views in health and disease
P Kandasamy, G Gyimesi, Y Kanai… - Trends in biochemical …, 2018 - cell.com
Amino acid transporters (AATs) are membrane-bound transport proteins that mediate
transfer of amino acids into and out of cells or cellular organelles. AATs have diverse …
transfer of amino acids into and out of cells or cellular organelles. AATs have diverse …
Noninvasive tests accurately identify advanced fibrosis due to NASH: baseline data from the STELLAR trials
Accurate noninvasive tests (NITs) are needed to replace liver biopsy for identifying
advanced fibrosis caused by nonalcoholic steatohepatitis (NASH). We analyzed screening …
advanced fibrosis caused by nonalcoholic steatohepatitis (NASH). We analyzed screening …
The human SLC1A5 (ASCT2) amino acid transporter: from function to structure and role in cell biology
SLC1A5, known as ASCT2, is a neutral amino acid transporter belonging to the SLC1 family
and localized in the plasma membrane of several body districts. ASCT2 is an acronym …
and localized in the plasma membrane of several body districts. ASCT2 is an acronym …
A flexible split prime editor using truncated reverse transcriptase improves dual-AAV delivery in mouse liver
Prime editor (PE) has tremendous promise for gene therapy. However, it remains a
challenge to deliver PE (> 6.3 kb) in vivo. Although PE can be split into two fragments and …
challenge to deliver PE (> 6.3 kb) in vivo. Although PE can be split into two fragments and …
DNMT1-mediated methylation of BEX1 regulates stemness and tumorigenicity in liver cancer
Q Wang, N Liang, T Yang, Y Li, J Li, Q Huang, C Wu… - Journal of …, 2021 - Elsevier
Background & Aims Hepatoblastoma (HB) and hepatocellular carcinoma (HCC) both exhibit
notable cancer stem cell (CSC) features. Moreover, the development of both diseases is …
notable cancer stem cell (CSC) features. Moreover, the development of both diseases is …
Heat shock proteins and HSF1 in cancer
AM Cyran, A Zhitkovich - Frontiers in oncology, 2022 - frontiersin.org
Fitness of cells is dependent on protein homeostasis which is maintained by cooperative
activities of protein chaperones and proteolytic machinery. Upon encountering protein …
activities of protein chaperones and proteolytic machinery. Upon encountering protein …
Targeting SLC1A5 and SLC3A2/SLC7A5 as a potential strategy to strengthen anti-tumor immunity in the tumor microenvironment
Cancer cells are metabolically vigorous and are superior in the uptake of nutrients and in the
release of the tumor microenvironment (TME)-specific metabolites. They create an acidic …
release of the tumor microenvironment (TME)-specific metabolites. They create an acidic …