The fast technological development, particularly single nucleotide polymorphism array, array-
comparative genomic hybridization, and whole exome sequencing, has led to the discovery …

Highlights•LTP induction promotes the localization of Wnt7a/b protein at dendritic
spines.•Wnt-Frizzled signaling is required for NMDA receptor-dependent LTP.•Wnt7a …

Mounting evidence indicates that Wnt signaling is relevant to pathophysiology of diverse
mental illnesses including schizophrenia, bipolar disorder, and autism spectrum disorder. In …

The structural and functional plasticity of synapses is critical for learning and memory. Long-
term potentiation (LTP) induction promotes spine growth and AMPAR accumulation at …

Autism spectrum disorder (ASD) is a group of neurodevelopmental disorders with a strong
genetic liability. Despite extensive studies, however, the underlying pathogenic mechanism …

Wnt signaling controls multiple biological process, particularly the embryonic development
of metazoans. Sustained expression of Wnt signaling components in the mature mammalian …

Stability of neuronal connectivity is critical for brain functions, and morphological
perturbations are associated with neurodegenerative disorders. However, how neuronal …

Despite the rapid advance over the past decades to design effective therapeutic
pharmacological interventions, chronic pain remains to be an unresolved healthcare …

Synapse loss strongly correlates with cognitive decline in Alzheimer's disease (AD), but the
underlying mechanisms are poorly understood. Deficient Wnt signaling contributes to …

Memories already consolidated when reactivated return to a labile state and can be
modified, this process is known as reconsolidation. It is known the Wnt signaling pathways …