Inflammation is increasingly recognized as being of both physiological and pathological
importance in the immature brain. The rationale of this review is to present an update on this …

Inflammation plays a critical role in mediating brain injury induced by neonatal hypoxic
ischemic encephalopathy (HIE). The mechanisms underlying inflammatory responses to …

Hypoxic ischemia is a common cause of damage to the fetal and neonatal brain. Although
systemic and cerebrovascular physiologic factors play an important role in the initial phases …

Induction of proinflammatory cytokines has been proposed to be a link between prenatal
maternal intrauterine infection and neonatal brain damage. It is known that the endotoxin …

Microglia are a heterogenous group of monocyte-derived cells serving multiple roles within
the brain, many of which are associated with immune and macrophage like properties …

Human epidemiological studies have provided compelling evidence that the risk of
developing schizophrenia is significantly enhanced following prenatal and/or perinatal …

Neurotrophins activate several different intracellular signaling pathways that in some way
exert neuroprotective effects. In vitro studies of sympathetic and cerebellar granule neurons …

Stressful events promote neurochemical changes that may be involved in the provocation of
depressive disorder. In addition to neuroendocrine substrates (eg corticotropin releasing …

The application of diffusion tensor imaging (DTI) to the evaluation of developing brain
remains an area of active investigation. This review focuses on the changes in DTI …

Programmed cell death (apoptosis) is a normal process in the developing nervous system.
Recent data suggest that certain features seen in the process of programmed cell death may …