Proteins are continuously affected by various intrinsic and extrinsic factors. Damaged
proteins influence several intracellular pathways and result in different disorders and …

Telomere repeat binding factor 2 (TRF2) has a well-known function at the telomeres, which
acts to protect the telomere end from being recognized as a DNA break or from unwanted …

Many cancers harbor homologous recombination defects (HRDs). A HRD is a therapeutic
target that is being successfully utilized in treatment of breast/ovarian cancer via synthetic …

It has been reported that oxidative stress (OS) is involved in the pathogenesis of
osteoarthritis (OA) and that defective autophagy is accompanying this age-related disease …

Background Human mesenchymal stem cells (MSC) are important tools for several cell-
based therapies. However, their use in such therapies requires in vitro expansion during …

Aims Lung cancer is one of the main causes of cancer-related deaths worldwide and
radiotherapy is a major treatment of choice. However, radioresistance is a main reason for …

Oxidative stress (OS) has been linked to the aetiology of many diseases including
osteoarthritis (OA). Recent studies have shown that caveolin-1—a structural protein of …

We recently reported that the inability of osteoarthritic (OA) chondrocytes to repair oxidative
stress (OS) induced DNA damage is linked to Cav-1 overexpression/improper localization …

Cellular senescence is a hallmark of aging characterized by irreversible growth arrest and
functional decline. Progressive telomeric DNA shortening in dividing somatic cells …

Purpose The use of chemotherapeutic agents to combat cancer is accompanied by high
toxicity due to their inability to discriminate between cancer and normal cells. Therefore …