Neutrophils are formidable defenders. Their vast numbers, constant production, high
cytotoxicity and capacity to produce extracellular traps, underlie their ability to efficiently …

Blood production depends on rare haematopoietic stem cells (HSCs) and haematopoietic
stem and progenitor cells (HSPCs) that ultimately take up residence in the bone marrow …

Tissue clearing combined with high-resolution confocal imaging is a cutting-edge approach
for dissecting the three-dimensional (3D) architecture of tissues and deciphering cellular …

Non-hematopoietic cells are essential contributors to hematopoiesis. However,
heterogeneity and spatial organization of these cells in human bone marrow remain largely …

Definitive haematopoiesis is the process by which haematopoietic stem cells, located in the
bone marrow, generate all haematopoietic cell lineages in healthy adults. Although highly …

Both cell-intrinsic and niche-derived, cell-extrinsic cues drive the specification of
hematopoietic multipotent progenitors (MPPs) in the bone marrow, which comprise …

The tissue microenvironment refers to a localised tissue area where a complex combination
of cells, structural components, and signalling molecules work together to support specific …

Bone marrow hematopoietic injury encompasses a range of pathological conditions that
disrupt the normal function of the hematopoietic system, primarily through the impaired …

Hematopoietic stem cells (HSC) and downstream lineage-biased multipotent progenitors
(MPP) tailor blood production and control myelopoiesis on demand. Recent lineage tracing …

Skeletal stem cells (SSCs) and related progenitors with osteogenic potential, collectively
termed skeletal stem and/or progenitor cells (SSPCs), are crucial for providing osteoblasts …