In this study, an electrochemical sensor based on graphene oxide (GO)/Zn-metal organic
framework (ZIF-8) composite electrode was used to detect acetaminophen (APAP). GO/ZIF-8 …

Millions of people suffer from arthritis worldwide, consistently struggling with daily activities
due to debilitating pain evoked by this disease. Perhaps the most intensively investigated …

The interoception maintains proper physiological conditions and metabolic homeostasis by
releasing regulatory signals after perceving changes in the internal state of the organism …

Purpose: To investigate the therapeutic effects of β-ecdysterone on osteoarthritis (OA) and
the underlying mechanism. Methods: OA model was established on rats by injecting MIA …

Macrophage polarization is a steering factor of osteoarthritis (OA) progression. Synovial fluid
(SF) obtained from OA patients with different Kellgren–Lawrence grades (KL grades) holds …

Nonsense-mediated mRNA decay (NMD) degrades transcripts with premature stop codons.
Given the prevalence of nonsense single nucleotide polymorphisms (SNPs) in the general …

Polygallic acid (PGAL) has been used in vitro to protect synoviocytes from monosodium
urate (MSU) crystals due to its anti-inflammatory properties. However, MSU crystals can also …

The prescribed use of non-steroidal anti-inflammatory drugs is associated with numerous life-
threatening side effects. There is a great need to develop low-dose NSAID formulations to …

Background and purpose Osteoarthritis (OA) is a chronic disease accompanied by severe
inflammation. The inflammation activation in the chondrocytes and the degradation of the …

For the first time, an electrochemical sensor was introduced by synthesizing a ZnO-Pd/Bi 2 O
3 nanocomposite into a carbon paste electrode (CPE). The sensor was utilized to …