Immune tolerance hinders the potentially destructive responses of lymphocytes to host
tissues. Tolerance is regulated at the stage of immature B cell development (central …

Common variable immunodeficiency (CVID) is a heterogeneous disorder characterized by
hypogammaglobulinemia and increased susceptibility to recurrent bacterial infections. It is …

Non-infectious complications in common variable immunodeficiency (CVID) have emerged
as a major clinical challenge. Detailed clinical spectrum, organ-specific pathologies and …

Fifty years have elapsed since the term common variable immunodeficiency (CVID) was
introduced to accommodate the many and varied antibody deficiencies being identified in …

A role for B cells in autoimmune diseases is now clearly established both in mouse models
and humans by successful treatment of multiple sclerosis and rheumatoid arthritis with anti …

Common variable immunodeficiency (CVID) is a primary antibody deficiency characterised
by hypogammaglobulinaemia, impaired production of specific antibodies after immunisation …

Highlights•TACI promotes TI antibody responses and controls autoimmunity and
lymphoproliferation.•TACI integrates signals from multiple pathways in B-cells to regulate …

The recombination-activating genes (RAG) 1 and 2 are indispensable for diversifying the
primary B cell receptor repertoire and pruning self-reactive clones via receptor editing in the …

Central B cell tolerance is believed to be regulated by B cell receptor signaling induced by
the recognition of self-antigens in immature B cells. Using humanized mice with defective …

Common variable immunodeficiency (CVID) is the most prevalent symptomatic primary
immunodeficiency and comprises a group of disorders with similar antibody deficiency but a …