Epileptogenesis

A Pitkänen, K Lukasiuk… - Cold Spring …, 2015 - perspectivesinmedicine.cshlp.org
Epileptogenesis is a chronic process that can be triggered by genetic or acquired factors,
and that can continue long after epilepsy diagnosis. In 2015, epileptogenesis is not a …

[HTML][HTML] Traumatic brain injury and epilepsy: underlying mechanisms leading to seizure

BP Lucke-Wold, L Nguyen, RC Turner, AF Logsdon… - Seizure, 2015 - Elsevier
Post-traumatic epilepsy continues to be a major concern for those experiencing traumatic
brain injury. Post-traumatic epilepsy accounts for 10–20% of epilepsy cases in the general …

Post-traumatic epilepsy and comorbidities: advanced models, molecular mechanisms, biomarkers, and novel therapeutic interventions

VM Golub, DS Reddy, C France - Pharmacological reviews, 2022 - Elsevier
Post-traumatic epilepsy (PTE) is one of the most devastating long-term, network
consequences of traumatic brain injury (TBI). There is currently no approved treatment that …

Herpes simplex virus type 1 and Alzheimer's disease: possible mechanisms and signposts

RF Itzhaki - The FASEB Journal, 2017 - Wiley Online Library
Support for the concept that herpes simplex virus type 1 (HSV1), when present in the brains
of apolipoprotein E‐«4 carriers, is a major risk for Alzheimer's disease (AD) is increasing …

[HTML][HTML] Epilepsy related to traumatic brain injury

A Pitkänen, R Immonen - Neurotherapeutics, 2014 - Elsevier
Post-traumatic epilepsy accounts for 10–20% of symptomatic epilepsy in the general
population and 5% of all epilepsy. During the last decade, an increasing number of …

[HTML][HTML] Epilepsy after traumatic brain injury

K Ding, PK Gupta, R Diaz-Arrastia - Translational research in …, 2016 - ncbi.nlm.nih.gov
An epileptic seizure is a “transient occurrence of signs and/or symptoms due to abnormal
excessive or synchronous neuronal activity in the brain.” 1 Epilepsy is a disorder of the brain …

Apolipoprotein E4 polymorphism and outcomes from traumatic brain injury: a living systematic review and meta-analysis

CA McFadyen, FA Zeiler, V Newcombe… - Journal of …, 2021 - liebertpub.com
The mortality of traumatic brain injury (TBI) has been largely static despite advances in
monitoring and imaging techniques. Substantial variance exists in outcome, not fully …

Traumatic brain injury history is associated with earlier age of onset of Alzheimer disease

C LoBue, H Wadsworth, K Wilmoth… - The Clinical …, 2017 - Taylor & Francis
Objective: This study examined whether a history of traumatic brain injury (TBI) is associated
with earlier onset of Alzheimer disease (AD), independent of apolipoprotein ε4 status …

Why we urgently need improved epilepsy therapies for adult patients

S Billakota, O Devinsky, KW Kim - Neuropharmacology, 2020 - Elsevier
Purpose Up to a third of patients with epilepsy suffer from recurrent seizures despite
therapeutic advances. Results Current epilepsy treatments are limited by experiential data …

The role of apolipoprotein E episilon (ɛ)-4 allele on outcome following traumatic brain injury: A systematic review

DW Lawrence, P Comper, MG Hutchison, B Sharma - Brain injury, 2015 - Taylor & Francis
Background: The apolipoprotein E gene (APOE) has emerged as a candidate for
prognosticating traumatic brain injury (TBI) recovery, with APOE ɛ 4 identified as a …