Virulence Potential and Treatment Options of Multidrug-Resistant (MDR) Acinetobacter baumannii

S Kumar, R Anwer, A Azzi - Microorganisms, 2021 - mdpi.com
Acinetobacter baumannii is an opportunistic pathogen which is undoubtedly known for a
high rate of morbidity and mortality in hospital-acquired infections. A. baumannii causes life …

Continuous manufacturing and molecular modeling of pharmaceutical amorphous solid dispersions

AG Nambiar, M Singh, AR Mali, DR Serrano… - AAPS …, 2022 - Springer
Amorphous solid dispersions enhance solubility and oral bioavailability of poorly water-
soluble drugs. The escalating number of drugs with poor aqueous solubility, poor …

Synergetic dual antibiotics-loaded chitosan/poly (vinyl alcohol) nanofibers with sustained antibacterial delivery for treatment of XDR bacteria-infected wounds

S Alizadeh, P Farshi, N Farahmandian… - International Journal of …, 2023 - Elsevier
Resistance of bacterial pathogens to conventional antibiotics has remained a significant
challenge in managing post-wound infections, especially in developing countries. Here, a …

Biofunctional hyaluronic acid/κ-carrageenan injectable hydrogels for improved drug delivery and wound healing

U Ijaz, M Sohail, M Usman Minhas, S Khan, Z Hussain… - Polymers, 2022 - mdpi.com
The in situ injectable hydrogel system offers a widespread range of biomedical applications
in prompt chronic wound treatment and management, as it provides self-healing, maintains …

Inhalable combination powder formulations of phage and ciprofloxacin for P. aeruginosa respiratory infections

Y Lin, RYK Chang, WJ Britton, S Morales… - European Journal of …, 2019 - Elsevier
Recently we showed that nebulized ciprofloxacin and phage PEV20 in combination had a
synergistic bactericidal effect against antibiotic-resistant Pseudomonas aeruginosa isolates …

Amorphous solid dispersion dry powder for pulmonary drug delivery: Advantages and challenges

K AboulFotouh, Y Zhang, M Maniruzzaman… - International Journal of …, 2020 - Elsevier
Amorphous solid dispersion (ASD) is commonly used in pharmaceutical industry. It has
been mainly employed to enhance the oral bioavailability of poorly water-soluble drugs that …

Development and characterization of meropenem dry powder inhaler formulation for pulmonary drug delivery

S Muneer, T Wang, L Rintoul, GA Ayoko, N Islam… - International Journal of …, 2020 - Elsevier
Meropenem (MPN), a broad spectrum β-lactam antibiotic, has been increasingly used in the
treatment of moderate to severe bacterial infections. However, due to its short plasma half …

Colistin Resistance among Enterobacteriaceae Isolated from Clinical Samples in Gaza Strip

M Qadi, S Alhato, R Khayyat… - Canadian journal of …, 2021 - Wiley Online Library
Bacterial infections, especially drug‐resistant infections, are a major global health issue. The
emergence of multidrug‐resistant (MDR) strains of Enterobacteriaceae and the lack of new …

[HTML][HTML] Quality by design–spray drying of ciprofloxacin-quercetin fixed-dose combination intended for inhalation

N Alhajj, NJ O'Reilly, H Cathcart - International Journal of Pharmaceutics, 2023 - Elsevier
Spray drying is a well-suited technique for producing fixed-dose drug combinations. There
has been a growing interest in utilizing spray drying to engineer carrier-free inhalable drug …

[HTML][HTML] Drug combination of ciprofloxacin and polymyxin b for the treatment of multidrug–resistant acinetobacter baumannii infections: a drug pair limiting the …

J Wang, M Stegger, A Moodley, M Yang - Pharmaceutics, 2023 - mdpi.com
Polymyxins are considered as last–resort antibiotics to treat infections caused by
Acinetobacter baumannii. However, there are increasing reports of resistance in A …