The accumulation of misfolded proteins in the human brain is one of the critical features of
many neurodegenerative diseases, including Alzheimer's disease (AD). Assembles of beta …

The RNA‐binding protein hnRNPA2/B1 is a member of the hnRNPs family and is widely
expressed in various tissues. hnRNPA2/B1 recognizes and binds specific RNA substrates …

Mutations in genes that encode RNA-binding proteins (RBPs) have emerged as critical
determinants of neurological diseases, especially motor neuron disorders such as …

Cortical hyperexcitability and mislocalization of the RNA-binding protein TDP43 are highly
conserved features in amyotrophic lateral sclerosis (ALS). Nevertheless, the relationship …

The cholinergic neurons of the basal forebrain (BF) provide virtually all of the brain's cortical
and amygdalar cholinergic input. They are particularly vulnerable to neuropathology in early …

Simple Summary The hnRNP A/B family of proteins (comprised of A1, A2/B1, A3, and A0)
contributes to the regulation of the majority of cellular RNAs. Here, we provide a …

Introduction Cholinergic dysfunction, demonstrated in the late 1970s and early 1980s, led to
the introduction of acetylcholinesterase inhibitors (AChEIs) in 1993 (Tacrine) to enhance …

Microglia express muscarinic G protein-coupled receptors (GPCRs) that sense cholinergic
activity and are activated by acetylcholine to potentially regulate microglial functions …

Objective Currently, most models of vascular cognitive impairment are established by
occluding the carotid arteries uni-or bilaterally to reduce the cerebral blood flow mimicking …

N6-methyladenosine (m6A) modification regulates RNA translation, splicing, transport,
localization, and stability at the post-transcriptional level. The m6A modification has been …