Clinical prediction of underlying pathologic substrates in people with Alzheimer's disease
(AD) dementia or related dementia syndromes (ADRD) has limited accuracy. Etiologic …

Congenital hydrocephalus occurs in one in 500–1000 babies born in the United States and
acquired hydrocephalus may occur as the consequence of stroke, intraventricular and …

Background Aggregation of α-synuclein (α-syn) is a prominent feature of Parkinson's
disease (PD) and other synucleinopathies. Currently, α-syn seed amplification assays …

Molecular biomarkers for neurodegenerative diseases are critical for advancing diagnosis
and therapy. Normal pressure hydrocephalus (NPH) is a neurological disorder …

Idiopathic normal pressure hydrocephalus (iNPH) is a neurological syndrome characterized
by the clinical triad of gait disorder, cognitive impairment and urinary incontinence. It has …

Background Normal pressure hydrocephalus (NPH) has drawn an increasing amount of
attention over the last 20 years. At present, there is a shortage of intuitive analysis on the …

Background and Objectives The assessment of biomarkers in selecting patients with
idiopathic normal pressure hydrocephalus (iNPH) for shunt surgery has been limited to …

Background and purpose Idiopathic normal pressure hydrocephalus (iNPH) pathogenesis is
multifactorial. Systemic inflammation might have a role in gathering clinical–pathological …

Introduction Huntington's disease (HD) is a hereditary neurodegenerative disease, currently
lacking disease-modifying treatments. Biomarkers are needed for objective assessment of …

Patients with idiopathic normal pressure hydrocephalus (iNPH) frequently show pathologic
CSF Aβ42 levels, comparable with Alzheimer's Disease (AD). Nevertheless, the clinical …