Potential pharmaceutical applications of quercetin in cardiovascular diseases

P Papakyriakopoulou, N Velidakis, E Khattab… - Pharmaceuticals, 2022 - mdpi.com
Quercetin, as a member of flavonoids, has emerged as a potential therapeutic agent in
cardiovascular diseases (CVDs) in recent decades. In this comprehensive literature review …

Recent advances and perspectives on the health benefits of urolithin B, a bioactive natural product derived from ellagitannins

P Chen, Z Guo, F Chen, Y Wu, B Zhou - Frontiers in pharmacology, 2022 - frontiersin.org
Urolithin (Uro) B is a natural compound produced by gut bacteria from ingested ellagitannins
(ETs) and ellagic acid (EA), complex polyphenols abundant in foods such as pomegranates …

Punicalagin ameliorates collagen-induced arthritis by downregulating M1 macrophage and pyroptosis via NF-κB signaling pathway

G Ge, J Bai, Q Wang, X Liang, H Tao, H Chen… - Science China Life …, 2022 - Springer
Rheumatoid arthritis (RA) is a chronic inflammatory disease that eventually leads to
disability. Inflammatory cell infiltration, severe joint breaking and systemic bone loss are the …

Therapeutic potential of quercetin as an antiatherosclerotic agent in atherosclerotic cardiovascular disease: a review

Q Deng, XX Li, Y Fang, X Chen… - … and Alternative Medicine, 2020 - Wiley Online Library
Atherosclerotic cardiovascular disease (ASCVD) is one of the diseases with the highest
morbidity and mortality globally. It causes a huge burden on families and caregivers and …

[HTML][HTML] Beneficial effects of pomegranate peel extract on plasma lipid profile, fatty acids levels and blood pressure in patients with diabetes mellitus type-2: A …

M Grabež, R Škrbić, MP Stojiljković… - Journal of Functional …, 2020 - Elsevier
Pomegranate peel contains high levels of various phytochemicals. We evaluated the effects
of pomegranate peel extract (PoPEx) consumption on plasma lipid profile, fatty acids (FA) …

Phytochemicals as modulators of paraoxonase-1 in health and diseases

ZN Arab, D Khayatan, SM Razavi, K Zare… - Antioxidants, 2022 - mdpi.com
Chronic diseases such as cardiovascular disease (CVD), atherosclerosis, chronic liver
disease, and neurodegenerative diseases are major causes of mortality. These diseases …

Towards a consensus on Alzheimer's disease comorbidity?

I Avitan, Y Halperin, T Saha, N Bloch… - Journal of clinical …, 2021 - mdpi.com
Alzheimer's disease (AD) is often comorbid with other pathologies. First, we review shortly
the diseases most associated with AD in the clinic. Then we query PubMed citations for the …

Urolithins: diet-derived bioavailable metabolites to tackle diabetes

AF Raimundo, S Ferreira, FA Tomás-Barberán… - Nutrients, 2021 - mdpi.com
Diabetes remains one of the leading causes of deaths and co-morbidities in the world, with
tremendous human, social and economic costs. Therefore, despite therapeutics and …

Punicalagin attenuates LPS-induced inflammation and ROS production in microglia by inhibiting the MAPK/NF-κB signaling pathway and NLRP3 inflammasome …

J Lo, CC Liu, YS Li, PY Lee, PL Liu, PC Wu… - Journal of …, 2022 - Taylor & Francis
Purpose Neurodegenerative diseases are associated with neuroinflammation along with
activation of microglia and oxidative stress, but currently lack effective treatments …

The role of punicalagin and its metabolites in atherosclerosis and risk factors associated with the disease

S Alalawi, F Albalawi, DP Ramji - International journal of molecular …, 2023 - mdpi.com
Atherosclerotic cardiovascular disease (ACVD) is the leading cause of death worldwide.
Although current therapies, such as statins, have led to a marked reduction in morbidity and …