Rheumatoid arthritis (RA) is an autoimmune disease characterized by chronic systemic
inflammation causing progressive joint damage that can lead to lifelong disability. The …

Coupling between bone formation and bone resorption refers to the process within basic
multicellular units in which resorption by osteoclasts is met by the generation of osteoblasts …

Macrophages are present in nearly all tissues and are critical for development, homeostasis,
and regeneration. Resident tissue macrophages of bone, termed osteal macrophages, are …

Breast cancer is the most common cancer affecting women worldwide, with bone
metastases presenting as the most common site of disease recurrence. Bone metastases …

The bone marrow (BM) microenvironment, also called the BM niche, is essential for the
maintenance of fully functional blood cell formation (hematopoiesis) throughout life. Under …

Type 1 diabetes (T1D) is caused by autoimmune destruction of insulin-producing β cells
located in the endocrine pancreas in areas known as islets of Langerhans. The current …

Hematopoiesis is the hierarchical process in which all lineages of blood cells are produced
by self-renewing hematopoietic stem cells (HSCs) in the bone marrow (BM). While the …

Hematopoietic stem/progenitor cell gene therapy (HSPC-GT) is proving successful to treat
several genetic diseases. HSPCs are mobilized, harvested, genetically corrected ex vivo …

Bone is in a constant state of remodeling, a process which was once attributed solely to
osteoblasts and osteoclasts. Decades of research has identified many other populations of …

The size and strength of bone is determined by two fundamental processes. One process,
bone remodelling, renews the skeleton throughout life. In this process existing bone is …