Expanding the role of the histone lysine-specific demethylase LSD1 in cancer
Studies of alterations in histone methylation in cancer have led to the identification of histone
methyltransferases and demethylases as novel targets for therapy. Lysine-specific …
methyltransferases and demethylases as novel targets for therapy. Lysine-specific …
Histone demethylases in chromatin biology and beyond
E Dimitrova, AH Turberfield, RJ Klose - EMBO reports, 2015 - embopress.org
Histone methylation plays fundamental roles in regulating chromatin‐based processes. With
the discovery of histone demethylases over a decade ago, it is now clear that histone …
the discovery of histone demethylases over a decade ago, it is now clear that histone …
A specific LSD1/KDM1A isoform regulates neuronal differentiation through H3K9 demethylation
Summary Lysine-specific demethylase 1 (LSD1) has been reported to repress and activate
transcription by mediating histone H3K4me1/2 and H3K9me1/2 demethylation, respectively …
transcription by mediating histone H3K4me1/2 and H3K9me1/2 demethylation, respectively …
[HTML][HTML] The histone LSD1 demethylase in stemness and cancer transcription programs
DNA and histone chromatin modifying enzymes play a crucial role in chromatin remodeling
in several biological processes. Lysine-specific demethylase 1 (LSD1), the first identified …
in several biological processes. Lysine-specific demethylase 1 (LSD1), the first identified …
Estrogen receptor signaling as a target for novel breast cancer therapeutics
JM Renoir, V Marsaud, G Lazennec - Biochemical pharmacology, 2013 - Elsevier
In breast cancer (BC) epithelial cells, the mitogenic action of estradiol is transduced through
binding to two receptors, ERα and ERβ, which act as transcription factors. Anti-estrogens …
binding to two receptors, ERα and ERβ, which act as transcription factors. Anti-estrogens …
Crystal structure of the LSD1/CoREST histone demethylase bound to its nucleosome substrate
LSD1 (lysine specific demethylase; also known as KDM1A), the first histone demethylase
discovered, regulates cell-fate determination and is overexpressed in multiple cancers …
discovered, regulates cell-fate determination and is overexpressed in multiple cancers …
A comprehensive review of lysine-specific demethylase 1 and its roles in cancer
A Hosseini, S Minucci - Epigenomics, 2017 - Taylor & Francis
Histone methylation plays a key role in the regulation of chromatin structure, and its
dynamics regulates important cellular processes. The investigation of the role of alterations …
dynamics regulates important cellular processes. The investigation of the role of alterations …
Readers of histone methylarginine marks
S Gayatri, MT Bedford - Biochimica et Biophysica Acta (BBA)-Gene …, 2014 - Elsevier
Arginine methylation is a common posttranslational modification (PTM) that alters roughly
0.5% of all arginine residues in the cells. There are three types of arginine methylation …
0.5% of all arginine residues in the cells. There are three types of arginine methylation …
Arginine methylation‐dependent LSD1 stability promotes invasion and metastasis of breast cancer
Abstract Histone lysine demethylase 1 (LSD 1), the first identified histone demethylase, is
overexpressed in multiple tumor types, including breast cancer. However, the mechanisms …
overexpressed in multiple tumor types, including breast cancer. However, the mechanisms …
Repression of LSD1 potentiates homologous recombination-proficient ovarian cancer to PARP inhibitors through down-regulation of BRCA1/2 and RAD51
L Tao, Y Zhou, X Pan, Y Luo, J Qiu, X Zhou… - Nature …, 2023 - nature.com
Poly (ADP-ribose) polymerase inhibitors (PARPi) are selectively active in ovarian cancer
(OC) with homologous recombination (HR) deficiency (HRD) caused by mutations in …
(OC) with homologous recombination (HR) deficiency (HRD) caused by mutations in …