Understanding high-dose, ultra-high dose rate, and spatially fractionated radiation therapy
The National Cancer Institute's Radiation Research Program, in collaboration with the
Radiosurgery Society, hosted a workshop called Understanding High-Dose, Ultra-High …
Radiosurgery Society, hosted a workshop called Understanding High-Dose, Ultra-High …
FLASH radiotherapy with photon beams
Ultra‐high‐dose rate “FLASH” radiotherapy (FLASH‐RT) has been shown to drastically
reduce normal tissue toxicities while being as efficacious as conventional dose rate …
reduce normal tissue toxicities while being as efficacious as conventional dose rate …
X-rays can trigger the FLASH effect: Ultra-high dose-rate synchrotron light source prevents normal brain injury after whole brain irradiation in mice
This study is the first proof of concept that the FLASH effect can be triggered by X-rays. Our
results show that a 10 Gy whole-brain irradiation delivered at ultra-high dose-rate with …
results show that a 10 Gy whole-brain irradiation delivered at ultra-high dose-rate with …
Comparative toxicity of synchrotron and conventional radiation therapy based on total and partial body irradiation in a murine model
LML Smyth, JF Donoghue, JA Ventura, J Livingstone… - Scientific reports, 2018 - nature.com
Synchrotron radiation can facilitate novel radiation therapy modalities such as microbeam
radiation therapy (MRT) and high dose-rate synchrotron broad-beam radiation therapy …
radiation therapy (MRT) and high dose-rate synchrotron broad-beam radiation therapy …
Toward an image-guided microbeam radiation therapy using gadolinium-based nanoparticles
G Le Duc, I Miladi, C Alric, P Mowat, E Bräuer-Krisch… - ACS …, 2011 - ACS Publications
Ultrasmall gadolinium-based nanoparticles (GBNs) induce both a positive contrast for
magnetic resonance imaging and a radiosentizing effect. The exploitation of these …
magnetic resonance imaging and a radiosentizing effect. The exploitation of these …
Preferential effect of synchrotron microbeam radiation therapy on intracerebral 9L gliosarcoma vascular networks
PURPOSE: Synchrotron microbeam radiation therapy (MRT) relies on spatial fractionation of
the incident photon beam into parallel micron-wide beams. Our aim was to analyze the …
the incident photon beam into parallel micron-wide beams. Our aim was to analyze the …
Proton‐minibeam radiation therapy: a proof of concept
Y Prezado, GR Fois - Medical physics, 2013 - Wiley Online Library
Purpose: This Monte Carlo simulation work aims at studying a new radiotherapy approach
called proton‐minibeam radiation therapy (pMBRT). The main objective of this proof of …
called proton‐minibeam radiation therapy (pMBRT). The main objective of this proof of …
Divide and conquer: spatially fractionated radiation therapy
Y Prezado - Expert reviews in molecular medicine, 2022 - cambridge.org
Spatially fractionated radiation therapy (SFRT) challenges some of the classical dogmas in
conventional radiotherapy. The highly modulated spatial dose distributions in SFRT have …
conventional radiotherapy. The highly modulated spatial dose distributions in SFRT have …
[HTML][HTML] Effects of microbeam radiation therapy on normal and tumoral blood vessels
A Bouchet, R Serduc, JA Laissue, V Djonov - Physica Medica, 2015 - Elsevier
Microbeam radiation therapy (MRT) is a new form of preclinical radiotherapy using quasi-
parallel arrays of synchrotron X-ray microbeams. While the deposition of several hundred …
parallel arrays of synchrotron X-ray microbeams. While the deposition of several hundred …
Hypoxia imaging and adaptive radiotherapy: a state-of-the-art approach in the management of glioma
M Gérard, A Corroyer-Dulmont, P Lesueur… - Frontiers in …, 2019 - frontiersin.org
Severe hypoxia [oxygen partial pressure (pO2) below 5–10 mmHg] is more frequent in
glioblastoma multiforme (GBM) compared to lower-grade gliomas. Seminal studies in the …
glioblastoma multiforme (GBM) compared to lower-grade gliomas. Seminal studies in the …