Reactive oxygen species (ROS)-responsive biomaterials mediate tissue microenvironments and tissue regeneration

Y Yao, H Zhang, Z Wang, J Ding, S Wang… - Journal of Materials …, 2019 - pubs.rsc.org
Reactive oxygen species (ROS) have been considered the pivotal signaling molecules in
many physiological processes, and are usually overproduced in various inflammatory …

Stimulus-cleavable chemistry in the field of controlled drug delivery

Y Xue, H Bai, B Peng, B Fang, J Baell, L Li… - Chemical Society …, 2021 - pubs.rsc.org
Stimulus-cleavable nanoscale drug delivery systems are receiving significant attention
owing to their capability of achieving exquisite control over drug release via the exposure to …

The chemistry of boronic acids in nanomaterials for drug delivery

A Stubelius, S Lee, A Almutairi - Accounts of chemical research, 2019 - ACS Publications
Conspectus Interest in increasing drug delivery efficiency has risen over the past decade
both as a means to improve efficacy of already clinically available drugs and due to the …

Harnessing inhaled nanoparticles to overcome the pulmonary barrier for respiratory disease therapy

Z Jin, Q Gao, K Wu, J Ouyang, W Guo… - Advanced Drug Delivery …, 2023 - Elsevier
The lack of effective treatments for pulmonary diseases presents a significant global health
burden, primarily due to the challenges posed by the pulmonary barrier that hinders drug …

H2O2-Responsive Vesicles Integrated with Transcutaneous Patches for Glucose-Mediated Insulin Delivery

X Hu, J Yu, C Qian, Y Lu, AR Kahkoska, Z Xie, X Jing… - ACS …, 2017 - ACS Publications
A self-regulated “smart” insulin administration system would be highly desirable for diabetes
management. Here, a glucose-responsive insulin delivery device, which integrates H2O2 …

Reactive oxygen species (ROS) responsive polymers for biomedical applications

Q Xu, C He, C Xiao, X Chen - Macromolecular bioscience, 2016 - Wiley Online Library
Reactive oxygen species (ROS) play important roles in cell signaling pathways, while
increased production of ROS may disrupt cellular homeostasis, giving rise to oxidative stress …

Integrated block copolymer prodrug nanoparticles for combination of tumor oxidative stress amplification and ROS-responsive drug release

W Yin, W Ke, W Chen, L Xi, Q Zhou, JF Mukerabigwi… - Biomaterials, 2019 - Elsevier
In tumor tissues, reactive oxygen species (ROS) level is significantly higher than that in
normal tissues, which has been frequently explored as the specific stimulus to trigger drug …

[HTML][HTML] Reactive oxygen species (ROS)-responsive size-reducible nanoassemblies for deeper atherosclerotic plaque penetration and enhanced macrophage …

J He, W Zhang, X Zhou, F Xu, J Zou, Q Zhang, Y Zhao… - Bioactive Materials, 2023 - Elsevier
Nanoparticle-based therapeutics represent potential strategies for treating atherosclerosis;
however, the complex plaque microenvironment poses a barrier for nanoparticles to target …

Applications of the ROS-responsive thioketal linker for the production of smart nanomedicines

A Rinaldi, R Caraffi, MV Grazioli, N Oddone, L Giardino… - Polymers, 2022 - mdpi.com
Reactive oxygen species (ROS)-sensitive drug delivery systems (DDS) specifically
responding to altered levels of ROS in the pathological microenvironment have emerged as …

Engineering of stimuli-responsive self-assembled biomimetic nanoparticles

N Krishnan, RH Fang, L Zhang - Advanced drug delivery reviews, 2021 - Elsevier
Nanoparticle-based therapeutics have the potential to change the paradigm of how we
approach the diagnosis and treatment of human disease. Employing naturally derived cell …