Major depressive disorder (MDD) is a highly prevalent psychiatric disorder and a major
cause of disability worldwide. This neurological condition is commonly associated with …

Transgenic mouse models have been used extensively to model the cognitive impairments
arising from Alzheimer's disease (AD)-related pathology. However, less is known about the …

Alzheimer's disease (AD), the most common form of dementia in late life, will become even
more prevalent by midcentury, constituting a major global health concern with huge …

Alzheimer's disease (AD) is an age-related dementia and neurodegenerative disorder,
characterized by Aβ and tau protein deposition impairing learning, memory and suppressing …

There is increasing evidence of prodromal manifestation of neuropsychiatric symptoms in a
variety of neurodegenerative diseases such as Parkinson's disease (PD) and Huntington's …

Alzheimer's disease (AD) pathology is commonly associated with cognitive decline but is
also composed of neuropsychiatric symptoms including psychological distress and …

Background Depression is highly related to Alzheimer's disease (AD), yet no effective
treatment is available. Phosphodiesterase-4 (PDE4) has been considered a promising …

Alzheimer's disease (AD) poses an ever-increasing public health concern as the population
ages, affecting more than 6 million Americans. AD patients present with mood and sleep …

Considerable clinical and epidemiological evidence links Alzheimer's disease (AD) and
depression. However, the molecular mechanisms underlying this connection are largely …

Impairment of biliverdin reductase-A (BVR-A) is an early event leading to brain insulin
resistance in AD. Intranasal insulin (INI) administration is under evaluation as a strategy to …