Ochratoxin A: 50 years of research

F Malir, V Ostry, A Pfohl-Leszkowicz, J Malir, J Toman - Toxins, 2016 - mdpi.com
Since ochratoxin A (OTA) was discovered, it has been ubiquitous as a natural contaminant
of moldy food and feed. The multiple toxic effects of OTA are a real threat for human beings …

Mycotoxins as human carcinogens—the IARC Monographs classification

V Ostry, F Malir, J Toman, Y Grosse - Mycotoxin research, 2017 - Springer
Humans are constantly exposed to mycotoxins (eg aflatoxins, ochratoxins), mainly via food
intake of plant and animal origin. The health risks stemming from mycotoxins may result from …

Mycotoxins and cellular senescence: the impact of oxidative stress, hypoxia, and immunosuppression

L You, E Nepovimova, M Valko, Q Wu, K Kuca - Archives of Toxicology, 2023 - Springer
Mycotoxins induce oxidative stress, hypoxia, and cause immunosuppressive effects.
Moreover, emerging evidence show that mycotoxins have a potential of inducing cellular …

Risk assessment of ochratoxin A in food

EFSA Panel on Contaminants in the Food Chain … - EFSA …, 2020 - Wiley Online Library
Abstract The European Commission asked EFSA to update their 2006 opinion on ochratoxin
A (OTA) in food. OTA is produced by fungi of the genus Aspergillus and Penicillium and …

Ochratoxin A-induced cytotoxicity, genotoxicity and reactive oxygen species in kidney cells: An integrative approach of complementary endpoints

JG Costa, N Saraiva, PS Guerreiro, H Louro… - Food and Chemical …, 2016 - Elsevier
Ochratoxin A (OTA) is a well-known nephrotoxic and potential carcinogenic agent but no
consensus about the molecular mechanisms underlying its deleterious effects has been …

Cytotoxicity, genotoxicity and disturbance of cell cycle in HepG2 cells exposed to OTA and BEA: single and combined actions

A Juan-García, J Tolosa, C Juan, MJ Ruiz - Toxins, 2019 - mdpi.com
Mycotoxins are produced by a number of fungal genera spp., for example, Aspergillus,
Penicillium, Alternaria, Fusarium, and Claviceps. Beauvericin (BEA) and Ochratoxin A (OTA) …

Metabolic disruption by naturally occurring mycotoxins in circulation: a focus on vascular and bone homeostasis dysfunction

AM Malvandi, S Shahba, J Mehrzad… - Frontiers in nutrition, 2022 - frontiersin.org
Naturally occurring food/feed contaminants have become a significant global issue due to
animal and human health implications. Despite risk assessments and legislation setpoints …

Cytotoxicity of the mycotoxins deoxynivalenol and ochratoxin A on Caco-2 cell line in presence of resveratrol

G Cano-Sancho, CA González-Arias, AJ Ramos… - Toxicology in Vitro, 2015 - Elsevier
Exposure to mycotoxins through dietary food intake involves a highly complex scenario
where co-contamination of different mycotoxins has been frequently demonstrated. On the …

Graphene oxide synergy with the conjugation of DNA and quantum dots for the sensitive detection of ochratoxin A

Q Li, Y Kang, S Yin, Y Qian, Y Cai, Z Yang - Food Analytical Methods, 2022 - Springer
Ochratoxin A (OTA) is one of the most common toxins in food and feed, which seriously
affects the health of public. Herein, a convenient biosensor for OTA detecting was built …

Genotoxic effects of the ochratoxin A (OTA), its main metabolite (OTα) per se and in combination with fumonisin B1 in HepG2 cells and human lymphocytes

RAM Alfonso, BHY Yvette, MDI Martha… - … /Genetic Toxicology and …, 2022 - Elsevier
Ochratoxin A (OTA) and fumonisin B 1 (FB 1) are mycotoxins distributed in a wide variety of
foods for human or animal consumption and are classified as possible carcinogens for …