Cachexia is the involuntary loss of muscle and adipose tissue that strongly affects mortality
and treatment efficacy in patients with cancer or chronic inflammatory disease. Currently, no …

Increasing evidences suggest that inflammation plays a key role in the pathogenesis of
stroke, a devastating disease second only to cardiac ischemia as a cause of death …

Sarcopenia is the decline of muscle mass and strength with age. Evidence suggests that
oxidative stress and molecular inflammation play important roles in age-related muscle …

TWEAK is a multifunctional cytokine that controls many cellular activities including
proliferation, migration, differentiation, apoptosis, angiogenesis and inflammation. TWEAK …

A transient increase in local pro-inflammatory cytokine expression following skeletal muscle
injury mediates the repair and regeneration of damaged myofibers through myogenesis …

Skeletal muscle atrophy/wasting is a serious complication of a wide range of diseases and
conditions such as aging, disuse, AIDS, chronic obstructive pulmonary disease, space …

Adult skeletal muscle has a robust capacity for self-repair, owing to synergies between
muscle satellite cells and the immune system. In vitro models of muscle self-repair would …

Myoblast fusion is a critical process that contributes to the growth of muscle during
development and to the regeneration of myofibers upon injury. Myoblasts fuse with each …

Skeletal muscle wasting is a major human morbidity, and contributes to mortality in a variety
of clinical settings, including denervation and cancer cachexia. In this study, we demonstrate …

First described as a weak apoptosis inducer, the TNF superfamily ligand TWEAK has since
emerged as a cytokine that regulates multiple cellular responses, including proinflammatory …