Critical periods in amblyopia

TK Hensch, EM Quinlan - Visual neuroscience, 2018 - cambridge.org
The shift in ocular dominance (OD) of binocular neurons induced by monocular deprivation
is the canonical model of synaptic plasticity confined to a postnatal critical period …

Parvalbumin-positive interneurons regulate cortical sensory plasticity in adulthood and development through shared mechanisms

DD Rupert, SD Shea - Frontiers in Neural Circuits, 2022 - frontiersin.org
Parvalbumin-positive neurons are the largest class of GABAergic, inhibitory neurons in the
central nervous system. In the cortex, these fast-spiking cells provide feedforward and …

Dynamic DNA methylation in the brain: a new epigenetic mark for experience-dependent plasticity

P Tognini, D Napoli, T Pizzorusso - Frontiers in cellular neuroscience, 2015 - frontiersin.org
Experience-dependent plasticity is the ability of brain circuits to undergo molecular,
structural and functional changes as a function of neural activity. Neural activity continuously …

Inhibitory interneurons in visual cortical plasticity

D van Versendaal, CN Levelt - Cellular and Molecular Life Sciences, 2016 - Springer
For proper maturation of the neocortex and acquisition of specific functions and skills,
exposure to sensory stimuli is vital during critical periods of development when synaptic …

Thalamic inhibition regulates critical-period plasticity in visual cortex and thalamus

JP Sommeijer, M Ahmadlou, MH Saiepour… - Nature …, 2017 - nature.com
During critical periods of development, experience shapes cortical circuits, resulting in the
acquisition of functions used throughout life. The classic example of critical-period plasticity …

Contrasting roles for parvalbumin-expressing inhibitory neurons in two forms of adult visual cortical plasticity

ES Kaplan, SF Cooke, RW Komorowski, AA Chubykin… - elife, 2016 - elifesciences.org
The roles played by cortical inhibitory neurons in experience-dependent plasticity are not
well understood. Here we evaluate the participation of parvalbumin-expressing (PV+) …

Enhancement of visual cortex plasticity by dark exposure

I Erchova, A Vasalauskaite… - … Transactions of the …, 2017 - royalsocietypublishing.org
Dark rearing is known to delay the time course of the critical period for ocular dominance
plasticity in the visual cortex. Recent evidence suggests that a period of dark exposure (DE) …

Interactions between excitatory neurons and parvalbumin interneurons in V1 underlie neural mechanisms of amblyopia and visual stimulation treatment

Y Huang, Z Liu, Z Zhan, X Zhang, L Gao… - Communications …, 2024 - nature.com
As the main cause of visual function deficits in children and adolescents worldwide,
amblyopia causes serious impairment of monocular visual acuity and stereopsis. The …

Low-intensity repetitive transcranial magnetic stimulation requires concurrent visual system activity to modulate visual evoked potentials in adult mice

K Makowiecki, A Garrett, AR Harvey, J Rodger - Scientific reports, 2018 - nature.com
Repetitive transcranial stimulation (rTMS) is an increasingly popular method to non-
invasively modulate cortical excitability in research and clinical settings. During rTMS, low …

Visual processing by calretinin expressing inhibitory neurons in mouse primary visual cortex

D Camillo, M Ahmadlou, MH Saiepour… - Scientific reports, 2018 - nature.com
Inhibition in the cerebral cortex is delivered by a variety of GABAergic interneurons. These
cells have been categorized by their morphology, physiology, gene expression and …