The 60-year evolution of lipid nanoparticles for nucleic acid delivery

PR Cullis, PL Felgner - Nature Reviews Drug Discovery, 2024 - nature.com
Delivery of genetic information to the interior of target cells in vivo has been a major
challenge facing gene therapies. This barrier is now being overcome, owing in part to …

A review post-vaccination SARS-CoV-2 serological test: Method and antibody titer response

MJ Devi, S Gaffar, YW Hartati - Analytical Biochemistry, 2022 - Elsevier
The development of the Coronavirus disease 2019 (COVID-19) vaccine is one of the most
important efforts in controlling the pandemic. Serological tests are used to identify highly …

Quantitative analysis of anti-N and anti-S antibody titers of SARS-CoV-2 infection after the third dose of COVID-19 vaccination

N Lee, S Jeong, SK Lee, EJ Cho, J Hyun, MJ Park… - Vaccines, 2022 - mdpi.com
We quantitatively analyzed SARS-CoV-2 antibody levels in patients after two doses of the
ChAdOx1 nCoV-19 vaccine and the third BNT162b2 booster. We obtained 255 serum …

Primary exposure to SARS-CoV-2 via infection or vaccination determines mucosal antibody-dependent ACE2 binding inhibition

J Fröberg, VJCH Koomen… - The Journal of …, 2024 - academic.oup.com
Background Mucosal antibodies play a critical role in preventing SARS-CoV-2 infections or
reinfections by blocking the interaction of the receptor-binding domain (RBD) with the …

Heterogeneity in spatial inequities in COVID-19 vaccination across 16 large US cities

U Bilal, PH Mullachery, A Schnake-Mahl… - American journal of …, 2022 - academic.oup.com
Differences in vaccination coverage can perpetuate coronavirus disease 2019 (COVID-19)
disparities. We explored the association between neighborhood-level social vulnerability …

Comparison of humoral and cellular immune responses between ChAd-BNT heterologous vaccination and BNT-BNT homologous vaccination following the third BNT …

W Sim, H Kang, J Jung, J Lee, GY Ko, HS Park… - Frontiers in …, 2023 - frontiersin.org
Introduction The differential immune responses after two additional BNT162b2 (BNT)
booster doses between ChAdOx1 nCoV-10 (ChAd)-primed and BNT-primed groups have …

Neutralizing antibodies against SARS-CoV-2 are higher but decline faster in mRNA vaccinees compared to individuals with natural infection

H Abou-Saleh, BY Abo-Halawa… - Journal of Travel …, 2022 - academic.oup.com
Background Waning protection against emerging SARS-CoV-2 variants by pre-existing
antibodies elicited because of current vaccination or natural infection is a global concern …

Elevated BMI reduces the humoral response to SARS‐CoV‐2 infection

MZW Tong, JDJ Sng, M Carney… - Clinical & …, 2023 - Wiley Online Library
Objective Class III obesity (body mass index [BMI]≥ 40 kg m− 2) significantly impairs the
immune response to SARS‐CoV‐2 vaccination. However, the effect of an elevated BMI (≥ …

Centenarians, semi and supercentenarians, COVID-19 and Spanish flu: a serological assessment to gain insight into the resilience of older centenarians to COVID-19

CM Trombetta, G Accardi, A Aiello, A Calabrò… - Immunity & …, 2024 - Springer
Background Although it is well known that the older people have been the most susceptible
to COVID-19, there are conflicting data on the susceptibility of centenarians. Two …

The rapid progress in COVID vaccine development and implementation

ADT Barrett, RW Titball, PA MacAry, RE Rupp… - npj Vaccines, 2022 - nature.com
January 2022 is the second anniversary of the identification of Coronavirus disease 2019
(COVID-19) 1 caused by severe acute respiratory syndrome (SARS) coronavirus 2 (SARS …