Cells must tightly regulate their gene expression programs and yet rapidly respond to acute
biochemical and biophysical cues within their environment. This information is transmitted to …

Mammals undergo regular cycles of fasting and feeding that engage dynamic transcriptional
responses in metabolic tissues. Here we review advances in our understanding of the gene …

Abstract Transposase-Accessible Chromatin followed by sequencing (ATAC-seq) is a
simple protocol for detection of open chromatin. Computational footprinting, the search for …

Primary hepatocytes are a vital tool in various biomedical research disciplines, serving as an
ex vivo model for liver physiology. Obtaining high yields of viable primary mouse …

Simultaneous measurements of transcriptomic and epigenomic profiles in the same
individual cells provide an unprecedented opportunity to understand cell fates. However …

Fasting and starvation were common occurrences during human evolution and accordingly
have been an important environmental factor shaping human energy metabolism. Humans …

Fasting metabolism and immunity are tightly linked; however, it is largely unknown how
immune cells contribute to metabolic homeostasis during fasting in healthy subjects. Here …

The circadian clock operates as intrinsic time-keeping machinery to preserve homeostasis in
response to the changing environment. While food is a known zeitgeber for clocks in …

Pioneer transcription factors are able to bind a partially exposed motif on the surface of a
nucleosome, enabling the proteins to target sites in silent regions of chromatin that have …

Glucocorticoids are adrenally produced hormones critically involved in development,
general physiology, and control of inflammation. Since their discovery, glucocorticoids have …