Therapeutic targets of oxidative/nitrosative stress and neuroinflammation in ischemic stroke: Applications for natural product efficacy with omics and systemic biology

H Chen, Y He, S Chen, S Qi, J Shen - Pharmacological Research, 2020 - Elsevier
Oxidative/nitrosative stress and neuroinflammation are critical pathological processes in
cerebral ischemia-reperfusion injury, and their intimate interactions mediate neuronal …

Oxidative stress and Parkinson's disease: new hopes in treatment with herbal antioxidants

A Sarrafchi, M Bahmani, H Shirzad… - Current …, 2016 - ingentaconnect.com
Parkinson's disease (PD) is a neurodegenerative disorder due to dopamine deficit in
substatia nigra. PD is mainly a sporadic disease with unestablished etiology. However …

Salvianolic acid A protects against diabetic nephropathy through ameliorating glomerular endothelial dysfunction via inhibiting AGE-RAGE signaling

B Hou, G Qiang, Y Zhao, X Yang, X Chen… - Cellular Physiology and …, 2018 - karger.com
Abstract Background/Aims: Glomerular endothelium dysfunction leads to the progression of
renal architectonic and functional abnormalities in early-stage diabetic nephropathy (DN) …

Recent advances in herbal medicines treating Parkinson's disease

X Li, S Zhang, S Liu, F Lu - Fitoterapia, 2013 - Elsevier
Herbal medicines have attracted considerable attention in recent years, which are used to
treat Parkinson's disease (PD) in China based on traditional Chinese medicine or modern …

Challenges and improvements of novel therapies for ischemic stroke

L Yang, J Qian, B Yang, Q He, J Wang… - Frontiers in …, 2021 - frontiersin.org
Stroke is the third most common disease all over the world, which is regarded as a hotspot in
medical research because of its high mortality and morbidity. Stroke, especially ischemic …

Effects of the Nrf2 protein modulator salvianolic acid A alone or combined with metformin on diabetes-associated macrovascular and renal injury

P Wu, Y Yan, L Ma, B Hou, Y He, L Zhang, Z Niu… - Journal of Biological …, 2016 - ASBMB
Nuclear factor E2-related factor 2 (Nrf2) is considered a promising target against diabetic
complications such as cardiovascular diseases and diabetic nephropathy. Herein, we …

α-Arbutin protects against Parkinson's disease-associated mitochondrial dysfunction in vitro and in vivo

Y Ding, D Kong, T Zhou, N Yang, C Xin, J Xu… - Neuromolecular …, 2020 - Springer
Abstract Parkinson's disease (PD), the most common neurodegenerative movement
disorder, is characterized by the progressive loss of dopaminergic neurons in substantia …

Identification of Potential Metabolites Mediating Bird's Selective Feeding on Prunus mira Flowers

S Zhang, H Ying, G Pingcuo, S Wang… - BioMed research …, 2019 - Wiley Online Library
In peach orchards, birds severely damage flowers during blossom season, decreasing the
fruit yield potential. However, the wild peach species Prunus mira shows intraspecific …

Novel prenylated indole alkaloids with neuroprotection on SH-SY5Y cells against oxidative stress targeting Keap1–Nrf2

X Xiao, Z Tong, Y Zhang, H Zhou, M Luo, T Hu, P Hu… - Marine Drugs, 2022 - mdpi.com
Oxidative stress has been implicated in the etiology of Parkinson's disease (PD). Molecules
non-covalently binding to the Keap1–Nrf2 complex could be a promising therapeutic …

Therapeutic potential of Salviae miltiorrhizae radix et rhizoma against human diseases based on activation of Nrf2‐mediated antioxidant defense system: bioactive …

GH Li, YR Li, P Jiao, Y Zhao, HX Hu… - Oxidative Medicine …, 2018 - Wiley Online Library
Oxidative stress plays a central role in the pathogenesis of many human diseases. The
nuclear factor erythroid 2‐related factor 2 (Nrf2) is a key transcription factor regulating the …