Little fish, big data: zebrafish as a model for cardiovascular and metabolic disease

P Gut, S Reischauer, DYR Stainier… - Physiological …, 2017 - journals.physiology.org
The burden of cardiovascular and metabolic diseases worldwide is staggering. The
emergence of systems approaches in biology promises new therapies, faster and cheaper …

The intrinsic cardiac nervous system and its role in cardiac pacemaking and conduction

L Fedele, T Brand - Journal of cardiovascular development and disease, 2020 - mdpi.com
The cardiac autonomic nervous system (CANS) plays a key role for the regulation of cardiac
activity with its dysregulation being involved in various heart diseases, such as cardiac …

Neurohumoral control of sinoatrial node activity and heart rate: insight from experimental models and findings from humans

EA MacDonald, RA Rose, TA Quinn - Frontiers in physiology, 2020 - frontiersin.org
The sinoatrial node is perhaps one of the most important tissues in the entire body: it is the
natural pacemaker of the heart, making it responsible for initiating each-and-every normal …

A critical review of zebrafish models of Parkinson's disease

JM Doyle, RP Croll - Frontiers in Pharmacology, 2022 - frontiersin.org
A wide variety of human diseases have been modelled in zebrafish, including various types
of cancer, cardiovascular diseases and neurodegenerative diseases like Alzheimer's and …

Development toxicity and cardiotoxicity in zebrafish from exposure to iprodione

Y Wei, Y Meng, Y Huang, Z Liu, K Zhong, J Ma… - Chemosphere, 2021 - Elsevier
Iprodione is a highly effective broad-spectrum fungicide commonly used for early disease
control in fruit trees and vegetables. Pesticides often flow into watercourses due to rainfall …

Cardiac form, function and physiology

AP Farrell, F Smith - Fish physiology, 2017 - Elsevier
Herein, we consider the heart as an organ whose task is to supply blood flow to the tissues.
A brief section on the form and function of the heart sets the stage for more detailed sections …

Identification of astroglia-like cardiac nexus glia that are critical regulators of cardiac development and function

NL Kikel-Coury, JP Brandt, IA Correia, MR O'Dea… - PLoS …, 2021 - journals.plos.org
Glial cells are essential for functionality of the nervous system. Growing evidence
underscores the importance of astrocytes; however, analogous astroglia in peripheral …

On the evolution of the cardiac pacemaker

S Burkhard, V Van Eif, L Garric, VM Christoffels… - Journal of …, 2017 - mdpi.com
The rhythmic contraction of the heart is initiated and controlled by an intrinsic pacemaker
system. Cardiac contractions commence at very early embryonic stages and coordination …

The goldfish Carassius auratus: an emerging animal model for comparative cardiac research

M Filice, MC Cerra, S Imbrogno - Journal of Comparative Physiology B, 2022 - Springer
The use of unconventional model organisms is significantly increasing in different fields of
research, widely contributing to advance life sciences understanding. Among fishes, the …

Regulation of cardiac function by the autonomic nervous system

OA Hafez, RB Chang - Physiology, 2024 - journals.physiology.org
The autonomic nervous system is critical for regulating cardiovascular physiology. The
neurocardiac axis encompasses multiple levels of control, including the motor circuits of the …