Acute myeloid leukemia (AML) is the most common acute leukemia in adults. While survival
for younger patients over the last several decades has improved nearly sixfold with the …

Protein film electrochemistry (PFE) has given unrivalled insight into the properties of redox
proteins and many electron-transferring enzymes, allowing investigations of otherwise ill …

Abstract Isocitrate dehydrogenase (IDH) 1 and 2, as essential enzymes in energy
metabolism, contribute to the survival and drug resistance of a variety of solid tumors …

The importance of international collaboration in the research field is well-documented, but its
impact on the number of citations received by research publications is not fully understood …

Isocitrate dehydrogenase 1 (IDH1) naturally copurifies and crystallizes in a resting state with
a molecule of its exchangeable cofactor, NADP+/NADPH, bound in each monomer of the …

Gliomas are the most common primary brain tumor and are uniformly lethal. Despite
significant advancements in understanding the genetic landscape of gliomas, standard-of …

The discovery of isocitrate dehydrogenase 1 (IDH1) mutations in acute myeloid leukemia
(AML) and the resounding success of molecularly targeted therapies in related myeloid …

The ability to control enzyme cascades entrapped in a nanoporous electrode material (the
“Electrochemical Leaf”, e‐Leaf) has been exploited to gain detailed kinetic insight into the …

Conclusions: IDH1-mutant CCA is characterized by increased abundance of M2-like TAMs.
Targeting CCL2 remodels the tumor immune microenvironment and improves outcomes in …

Introduction The development of oral therapies impacts the management of acute myeloid
leukemia and myelodysplastic syndromes, especially for targetable mutations including …