Macromolecular crystallography at synchrotron sources has proven to be the most influential
method within structural biology, producing thousands of structures since its inception. While …

The advent and application of the X-ray free-electron laser (XFEL) has uncovered the
structures of proteins that could not previously be solved using traditional crystallography …

Viral protein U (Vpu) is a type-III integral membrane protein encoded by Human
Immunodeficiency Virus-1 (HIV-1). It is expressed in infected host cells and plays several …

Bacterial superantigens (sAgs) are powerful activators of the immune response that trigger
unspecific T cell responses accompanied by the release of proinflammatory cytokines …

The cholera toxin B subunit (CTB) is a nontoxic portion of the cholera toxin that retains
mucosal adjuvant properties. Expression of CTB in Escherichia coli is difficult as CTB …

The transmembrane subunit (gp41) of the envelope glycoprotein of HIV‐1 associates
noncovalently with the surface subunit (gp120) and together they play essential roles in viral …

Time-resolved serial femtosecond crystallography is an emerging method that allows for
structural discovery to be performed on biomacromolecules during their dynamic trajectory …

X-ray crystallography is the most widely used method to determine the structure of proteins,
providing an understanding of their functions in all aspects of life to advance applications in …

In this chapter, the rational design for covalent inhibition, chemical synthesis and initial
biochemical testing of a disaccharide series LgtC-inhibitors is discussed. Before presenting …

The cattle industry worldwide is ravaged by bovine respiratory disease (BRD), a bacterial
disease caused by Mannheimia haemolytica. Recent efforts to design vaccines against M …