Emerging from the origins of supramolecular chemistry and the development of selective
chemical receptors that rely on lock‐and‐key binding, activity‐based sensing (ABS)—which …

Atherosclerosis is an inflammatory disease of the artery walls and involves immune cells
such as macrophages. Olfactory receptors (OLFRs) are G protein–coupled chemoreceptors …

TET proteins (methylcytosine dioxygenases) play an important role in the regulation of gene
expression. Dysregulation of their activity is associated with many serious pathogenic states …

Disease relapse and therapy resistance remain key challenges in treating multiple
myeloma. Underlying (epi-) mutational events can promote myelomagenesis and contribute …

In countries around the world, sleep deprivation represents a widespread problem affecting
school‐age children, teenagers, and adults. Acute sleep deprivation and more chronic sleep …

Autosomal dominant polycystic kidney disease (ADPKD), with an estimated genetic
prevalence between 1: 400 and 1: 1,000 individuals, is the third most common cause of end …

The recent emergence of oxidation state selective probes of cellular iron has produced a
more nuanced understanding of how cells utilize this crucial nutrient to empower enzyme …

Although transition metals constitute less than 0.1% of the total mass within a human body,
they have a substantial impact on fundamental biological processes across all kingdoms of …

Chemical tools capable of detecting ferrous iron with oxidation-state specificity have only
recently become available. Coincident with this development in chemical biology has been …

Iron is an essential micronutrient metal for cellular functions but can generate highly reactive
oxygen species resulting in oxidative damage. For these reasons its uptake and metabolism …