Bacterial persisters: molecular mechanisms and therapeutic development

H Niu, J Gu, Y Zhang - Signal transduction and targeted therapy, 2024 - nature.com
Persisters refer to genetically drug susceptible quiescent (non-growing or slow growing)
bacteria that survive in stress environments such as antibiotic exposure, acidic and …

[HTML][HTML] Bacterial biofilm eradication agents: a current review

AD Verderosa, M Totsika, KE Fairfull-Smith - Frontiers in chemistry, 2019 - frontiersin.org
Most free-living bacteria can attach to surfaces and aggregate to grow into multicellular
communities encased in extracellular polymeric substances called biofilms. Biofilms are …

Formation, physiology, ecology, evolution and clinical importance of bacterial persisters

B Van den Bergh, M Fauvart… - FEMS microbiology …, 2017 - academic.oup.com
Persisters are transiently tolerant variants that allow populations to avoid eradication by
antibiotic treatment. Their antibiotic tolerance is non-genetic, not inheritable and results from …

Targeting biofilms therapy: current research strategies and development hurdles

Y Jiang, M Geng, L Bai - Microorganisms, 2020 - mdpi.com
Biofilms are aggregate of microorganisms in which cells are frequently embedded within a
self-produced matrix of extracellular polymeric substance (EPS) and adhere to each other …

Nanoparticles for oral biofilm treatments

DSW Benoit, KR Sims Jr, D Fraser - ACS nano, 2019 - ACS Publications
Pathogenic oral biofilms are universal, chronic, and costly. Despite advances in
understanding the mechanisms of biofilm formation and persistence, novel and effective …

Fighting bacterial persistence: Current and emerging anti-persister strategies and therapeutics

V Defraine, M Fauvart, J Michiels - Drug Resistance Updates, 2018 - Elsevier
In addition to the well-known strategies of antibiotic resistance and biofilm formation,
bacterial populations possess an additional survival strategy to endure hostile environments …

Mechanisms of bacterial tolerance and persistence in the gastrointestinal and respiratory environments

R Trastoy, T Manso, L Fernández-García… - Clinical microbiology …, 2018 - Am Soc Microbiol
Pathogens that infect the gastrointestinal and respiratory tracts are subjected to intense
pressure due to the environmental conditions of the surroundings. This pressure has led to …

Strategies to combat multidrug-resistant and persistent infectious diseases

O Pacios, L Blasco, I Bleriot, L Fernandez-Garcia… - Antibiotics, 2020 - mdpi.com
Antibiotic failure is one of the most worrying health problems worldwide. We are currently
facing an international crisis with several problematic facets: new antibiotics are no longer …

Central venous catheters and biofilms: where do we stand in 2017?

M Gominet, F Compain, C Beloin, D Lebeaux - Apmis, 2017 - Wiley Online Library
The use of central venous catheters (CVC) is associated with a risk of microbial colonization
and subsequent potentially severe infection. Microbial contamination of the catheter leads to …

Challenges of antibiotic resistance biofilms and potential combating strategies: a review

J Khan, SM Tarar, I Gul, U Nawaz, M Arshad - 3 Biotech, 2021 - Springer
In this modern era, medicine is facing many alarming challenges. Among different
challenges, antibiotics are gaining importance. Recent years have seen unprecedented …