Cancer arises from a multitude of disorders resulting in loss of differentiation and a stem cell-
like phenotype characterized by uncontrolled growth. Polycomb Group (PcG) proteins are …

Abstract Neurofibromatosis type 1 (NF1) is an autosomal dominant tumour predisposition
syndrome that is caused through loss of function mutations of a tumour suppressor gene …

The gene encoding ARID1A, a chromatin remodeler, shows one of the highest mutation
rates across many cancer types. Notably, ARID1A is mutated in over 50% of ovarian clear …

Nuclear localization of HIPPO-YAP fusion proteins has been implicated in supratentorial
ependymoma development. Here, unexpectedly, we find that liquid–liquid phase separation …

Irregularities in nuclear shape and/or alterations to nuclear size are a hallmark of
malignancy in a broad range of cancer types. Though these abnormalities are commonly …

Motivation Chromosomal patterning of gene expression in cancer can arise from
aneuploidy, genome disorganization or abnormal DNA methylation. To map such patterns …

Surgery and chemo-radiotherapy are used as the common first-line treatment options in
many cancers. However, tumor relapse is observed in many cancer patients following such …

Background and objectives Enhancer of zeste 2 (EZH2), embryonic ectoderm development
(EED), and suppressor of zeste 12 homolog (SUZ12), the key component of polycomb …

Three-dimensional genome organization represents an additional layer in the epigenetic
regulation of gene expression. Active transcription controlled by enhancers or super …

Metformin has been used for the treatment of type II diabetes mellitus for decades. Recently,
used of metformin in the therapy of diverse human cancer types has received widespread …