Objective Use of the frailty index to measure an accumulation of deficits has been proven a
valuable method for identifying elderly people at risk for increased vulnerability, disease …

Somatic disturbances that occur in parallel with psychiatric diseases are a major challenge
in clinical practice. Various factors contribute to the development of mental and somatic …

Pancreatic β-cell failure is a critical event in the onset of both main types of diabetes mellitus
but underlying mechanisms are not fully understood. β-cells have low anti-oxidant capacity …

Objective Dedifferentiation of pancreatic β-cells may reduce islet function in type 2 diabetes
(T2D). However, the prevalence, plasticity and functional consequences of this cellular state …

Abstract The SARS-CoV-2 Spike protein mediates docking of the virus onto cells prior to
viral invasion. Several cellular receptors facilitate SARS-CoV-2 Spike docking at the cell …

Abstract Type 2 diabetes (T2D) is caused by an inherited predisposition to pancreatic islet β-
cell failure, which is manifested under cellular stress induced by metabolic overload. The …

Background and Objectives: A subject with diabetes and obesity is a class of the metabolic
disorder. The current investigation aimed to elucidate the potential biomarker and prognostic …

Abstract Background/Aims The risk of type 2 diabetes (T2D) is determined by a combination
of genetic and environmental factors. Multiple studies have proposed that long noncoding …

Maternal body mass index (BMI) before pregnancy is known to affect both fetal growth and
later-life health of the newborn, yet the implicated molecular mechanisms remain largely …

Objective β-cell dedifferentiation has been revealed as a pathological mechanism
underlying pancreatic dysfunction in diabetes. We previously showed that increased miR-7 …