In vitro cultured autologous mesenchymal stem cells (MSCs) within passage 5 have been
approved for clinical application in stem cell-based treatment of cartilage defects. However …

Aging is a multifactorial process characterized by the progressive deterioration of
physiological functions. Among the multiple molecular mechanisms, microRNAs (miRNAs) …

Microglia, the key innate immune cells in the brain, have been reported to drive brain aging
and neurodegenerative disorders; however, few studies have analyzed microglial …

Acute myeloid leukemia (AML) is the most prevalent form of acute leukemia. Patients with
AML often have poor clinical prognoses. Hypoxia can activate a series of …

Introduction Neuroinflammation and metabolic dysfunction are early alterations in
Alzheimer's disease (AD) brain that are thought to contribute to disease onset and …

Key points The embryonic PHOX2B‐progenitor domain generates neuronal and glial cells
which together are involved in chemosensory control of breathing and sleep homeostasis …

Circulating microRNAs (miRNAs) have emerged as diagnostic and prognostic biomarkers
for traumatic brain injury (TBI). However, a comprehensive characterization of the serum …

Background Ischemia–reperfusion injury to the central nervous system often causes severe
complications. The activation of endogenous neural stem cells (NSCs) is considered a …

Methods: We used Luminex XMAP technology to quantify hippocampal cytokine
concentrations in the 5xFAD mouse model of Alzheimer's disease at milestone timepoints in …

Congenital central hypoventilation syndrome (CCHS) represents a rare genetic disorder
usually caused by mutations in the homeodomain transcription factor PHOX2B. Some CCHS …