Many physiologic effects of l-glutamate, the major excitatory neurotransmitter in the
mammalian central nervous system, are mediated via signaling by ionotropic glutamate …

The mammalian ionotropic glutamate receptor family encodes 18 gene products that
coassemble to form ligand-gated ion channels containing an agonist recognition site, a …

Pain is an important survival and protection mechanism for animals. However,
chronic/persistent pain may be differentiated from normal physiological pain in that it confers …

A growing body of evidence indicates that repeated exposure to cocaine leads to profound
changes in glutamate transmission in limbic nuclei, particularly the nucleus accumbens. This …

Major antidepressant agents increase synaptic levels of monoamines. Although the
monoamine hypothesis of depression remains a cornerstone of our understanding of the …

Transmembrane AMPA receptor regulatory proteins (TARPs) and cornichon proteins (CNIH-
2/3) independently modulate AMPA receptor trafficking and gating. However, the potential …

There is an increasing body of evidence implicating a role for α-amino-3-hydroxy-5-methyl-4
isoxazoleproprionic acid (AMPA) receptors in major depression and in the actions of …

Presynaptic glutamate release elicits brief waves of membrane depolarization in neurons by
activating AMPA receptors. Depending on its precise size and shape, current through AMPA …

Abraham WC, Logan B, Greenwood JM, Dragunow M (2002) Induction and experience-
dependent consolidation of stable long-term potentiation lasting months in the …

Cochlear sound encoding depends on α-amino-3-hydroxy-5-methyl-4-isoxazole propionic
acid receptors (AMPARs), but reliance on specific pore-forming subunits is unknown. With 5 …