Genome‐wide association studies: utility and limitations for research in physiology
N Pereira Ciochetti, B Lugli‐Moraes… - The Journal of …, 2023 - Wiley Online Library
Physiological systems are subject to interindividual variation encoded by genetics. Genome‐
wide association studies (GWAS) operate by surveying thousands of genetic variants from a …
wide association studies (GWAS) operate by surveying thousands of genetic variants from a …
Is it time to end race and ethnicity adjustment for pediatric pulmonary function tests?
AL Non, K Akong, DJ Conrad - Pediatric Pulmonology, 2024 - Wiley Online Library
The continued inclusion of race in spirometry reference equations is a topic of intense
debate for adult lung function, but less discussion has focused on implications for children …
debate for adult lung function, but less discussion has focused on implications for children …
Genome-wide analysis in northern Chinese twins identifies twelve new susceptibility loci for pulmonary function
T Wang, W Wang, C Xu, X Tian, D Zhang - BMC genomics, 2024 - Springer
Background Previous genome-wide association studies (GWAS) have established
association between genetic variants and pulmonary function across various ethnics …
association between genetic variants and pulmonary function across various ethnics …
Adam19 Deficiency Impacts Pulmonary Function: Human GWAS Follow-up in a Mouse Knockout Model
Purpose Over 550 loci have been associated with human pulmonary function in genome-
wide association studies (GWAS); however, the causal role of most remains uncertain …
wide association studies (GWAS); however, the causal role of most remains uncertain …
[HTML][HTML] Adam19 Deficiency Impacts Pulmonary Function: Human GWAS Follow-up in Mouse
Purpose Over 550 loci have been associated with human pulmonary function in genome-
wide association studies (GWAS); however, the causal role of most remains uncertain …
wide association studies (GWAS); however, the causal role of most remains uncertain …
Socioeconomic status across the early life course predicts gene expression signatures of disease and senescence
Background Socioeconomic status (SES) is associated with many chronic diseases,
indicators of senescence and mortality. However, the changing salience of SES in the …
indicators of senescence and mortality. However, the changing salience of SES in the …
Mapping Epigenetic Gene Variant Dynamics: Comparative Analysis of Frequency, Functional Impact and Trait Associations in African and European Populations
M Sinkala, G Retshabile, PT Mpangase, S Bamba… - medRxiv, 2024 - pmc.ncbi.nlm.nih.gov
Epigenetic modifications influence gene expression levels, impact organismal traits, and
play a role in the development of diseases. Therefore, variants in genes involved in …
play a role in the development of diseases. Therefore, variants in genes involved in …
Shared Genetic Architecture Between COVID-19 Severity and Alzheimer's Disease Across European and African Ancestries
J Chen, D Cammann, T Liu, Y Liu… - Research …, 2024 - researchsquare.com
The global outbreak of COVID-19, caused by the SARS-CoV-2 virus, has been linked to long-
term neurological complications, including an increased risk of Alzheimer's disease (AD) …
term neurological complications, including an increased risk of Alzheimer's disease (AD) …
Genome-wide association analyses in dairy heifers highlight genes overlapping with mouse and human fertility and human health traits
M Marrella, GP Schettini, M Morozyuk, A Walsh… - bioRxiv, 2024 - biorxiv.org
Heifer Infertility and disease are important challenges in dairy cattle production. We
investigated genetic differences between Holstein heifers with varying fertility potential and …
investigated genetic differences between Holstein heifers with varying fertility potential and …
Unveiling the role of Tdark genes in genetic diseases and phenotypes through bioinformatics-based functional enrichment and network analyses
In recent years, there has been growing interest in understanding the role of dark genes in
genetic diseases and phenotypes. Despite their lack of functional characterisation, dark …
genetic diseases and phenotypes. Despite their lack of functional characterisation, dark …