Molecular docking, pharmacokinetic studies, and in vivo pharmacological study of indole derivative 2-(5-methoxy-2-methyl-1H-indole-3-yl)-N′-[(E)-(3-nitrophenyl) …
Cisplatin is an efficient anticancer drug against various types of cancers however, its usage
involves side effects. We investigated the mechanisms of action of indole derivative, 2-(5 …
involves side effects. We investigated the mechanisms of action of indole derivative, 2-(5 …
Association of endothelial nitric oxide synthase gene variants with preeclampsia
Background Preeclampsia (PE) is a complex pregnancy hypertensive disorder with
multifaceted etiology. The endothelial nitric oxide synthase (eNOS) gene and nitric oxide …
multifaceted etiology. The endothelial nitric oxide synthase (eNOS) gene and nitric oxide …
A novel homozygous variant in the GLI1 underlies postaxial polydactyly in a large consanguineous family with intra familial variable phenotypes
Polydactyly is a human inherited disorder caused by to anomalies in the genes involved in
autopod development. The disorder segregates in both autosomal recessive and autosomal …
autopod development. The disorder segregates in both autosomal recessive and autosomal …
[HTML][HTML] Virtual screening-driven repositioning of etoposide as CD44 antagonist in breast cancer cells
C Aguirre-Alvarado, A Segura-Cabrera… - Oncotarget, 2016 - ncbi.nlm.nih.gov
CD44 is a receptor for hyaluronan (HA) that promotes epithelial-to-mesenchymal transition
(EMT), induces cancer stem cell (CSC) expansion, and favors metastasis. Thus, CD44 is a …
(EMT), induces cancer stem cell (CSC) expansion, and favors metastasis. Thus, CD44 is a …
Antagonistic role of Klotho-derived peptides dynamics in the pancreatic cancer treatment through obstructing WNT-1 and Frizzled binding
M Fakhar, M Gul, S Rashid - Biophysical Chemistry, 2018 - Elsevier
Klotho is an anti-aging protein that is engaged in the suppression of canonical WNT
signaling. In this study, we investigated the expression pattern of human WNTs and Klotho in …
signaling. In this study, we investigated the expression pattern of human WNTs and Klotho in …
Identification of potential Plk1 targets in a cell-cycle specific proteome through structural dynamics of kinase and Polo box-mediated interactions
Polo like kinase 1 (Plk1) is a key player in orchestrating the wide variety of cell-cycle events
ranging from centrosome maturation, mitotic entry, checkpoint recovery, transcriptional …
ranging from centrosome maturation, mitotic entry, checkpoint recovery, transcriptional …
Sulindac acetohydrazide derivative attenuates against cisplatin induced organ damage by modulation of antioxidant and inflammatory signaling pathways
This study aimed to explore the mechanisms of action of a sulindac acetohydrazide
derivative, N'-(4-dimethylaminobenzylidene)-2-1-(4-(methylsulfinyl) benzylidene)-5-fluoro-2 …
derivative, N'-(4-dimethylaminobenzylidene)-2-1-(4-(methylsulfinyl) benzylidene)-5-fluoro-2 …
Structural basis for Cullins and RING component inhibition: Targeting E3 ubiquitin pathway conductors for cancer therapeutics
Abstract Cullin (CUL)-RING E3 ubiquitin ligases (CRLs) are attractive therapeutic targets as
they regulate diverse biological processes important for cancer cell survival by conferring …
they regulate diverse biological processes important for cancer cell survival by conferring …
Inhibition of Janus kinases by tyrosine phosphorylation inhibitor, Tyrphostin AG-490
Janus kinases (JAKs) belong to a crucial family of tyrosine kinases, implicated in the patho-
physiology of multiple cancer types, and serve as striking therapeutic targets. To date, many …
physiology of multiple cancer types, and serve as striking therapeutic targets. To date, many …
Molecular dynamics and structural analysis of the binding of COP1 E3 ubiquitin ligase to β‐catenin and TRIB pseudokinases
S Zahid, S Basharat, M Fakhar… - … : Structure, Function, and …, 2022 - Wiley Online Library
Tribbles pseudokinases, Tribbles homolog 1 (TRIB1), Tribbles homolog 2 (TRIB2), and
Tribbles homolog 3 (TRIB3), bind to constitutive photomorphogenesis protein 1 (COP1) E3 …
Tribbles homolog 3 (TRIB3), bind to constitutive photomorphogenesis protein 1 (COP1) E3 …