Diabetes mellitus has become a serious and chronic metabolic disorder that results from a
complex interaction of genetic and environmental factors, principally characterized by …

Glycolysis, a simple pathway of glucose metabolism, critically regulates insulin secretion
and metabolic functions of various cells. Depending on cell types, rates of glycolysis are …

Glucokinase (GK) plays a key role in whole-body glucose homeostasis by catalyzing the
phosphorylation of glucose in cells that express this enzyme, such as pancreatic β cells and …

In diabetes mellitus, the excessive rate of glucose production from the liver is considered a
primary contributor for the development of hyperglycemia, in particular, fasting …

Diabetes highlights a growing epidemic imposing serious social economic crisis to the
countries around the globe. Despite scientific breakthroughs, better healthcare facilities, and …

Background Type 1 diabetes mellitus (T1DM) is an autoimmune disorder characterized by T
cell-mediated self-destruction of insulin-secreting islet β cells. Management of T1DM is …

The environmental toxin TCDD (2, 3, 7, 8-tetrachlorodibenzo-p-dioxin, dioxin) produces
diverse toxic effects including a lethal wasting syndrome whose hallmark is suppressed …

The effects of ursolic acid on the polyol pathway and glucose homeostasis–related
metabolism were examined in the livers of streptozotocin (STZ)-induced diabetic mice fed a …

OBJECTIVE Despite advances in exogenous insulin therapy, many patients with type 1
diabetes do not achieve acceptable glycemic control and remain at risk for ketosis and …

There has been an alarming increase in the population diagnosed with diabetes worldwide.
Although there is an ongoing debate as to the role of liver in the pathogenesis of diabetes …