The p53 family of proteins consists of p53, p63 and p73, which are transcription factors that
affect both cancer and development. It is now emerging that these proteins also regulate …

The ability to reproduce relies in most eukaryotes on specialized cells called gametes.
Gametes are formed by the process of meiosis in which, after a single round of replication …

During mitosis, replicated chromosomes (sister chromatids) become attached at the
kinetochore by spindle microtubules emanating from opposite poles and segregate …

Aurora B kinase (AURKB) is the catalytic subunit of the chromosomal passenger complex
(CPC), an essential regulator of chromosome segregation. In mitosis, the CPC is required to …

We previously isolated Aurora-C/Aie1 in a screen for kinases expressed in mouse sperm
and eggs. Here, we show the localization of endogenous Aurora-C and examine its roles …

Errors in chromosome segregation during female meiosis I occur frequently, and aneuploid
embryos account for 1/3 of all miscarriages in humans [1]. Unlike mitotic cells that require …

BACKGROUND Meiosis is a unique form of cell division in which cells divide twice but DNA
is duplicated only once. Errors in chromosome segregation during meiosis will result in …

The mammalian genome encodes three Aurora kinase protein family members: A, B, and C.
While Aurora kinase A (AURKA) and B (AURKB) are found in cells throughout the body …

Aurora kinases are highly conserved, essential regulators of cell division. Two Aurora kinase
isoforms, A and B (AURKA and AURKB), are expressed ubiquitously in mammals, whereas …

Errors in chromosome segregation in oocytes and early embryos lead to embryo
aneuploidy, which contributes to early pregnancy loss. At the heart of chromosome …