Smoking and endothelial dysfunction
Cigarette smoking is one of the most important health concerns worldwide. Even though the
rate of smoking is declining in developed countries, it is still experiencing growth in …
rate of smoking is declining in developed countries, it is still experiencing growth in …
Insulin/adenosine axis linked signalling
Regulation of blood flow depends on systemic and local release of vasoactive molecules
such as insulin and adenosine. These molecules cause vasodilation by activation of plasma …
such as insulin and adenosine. These molecules cause vasodilation by activation of plasma …
Mice long-term high-fat diet feeding recapitulates human cardiovascular alterations: an animal model to study the early phases of diabetic cardiomyopathy
SD Calligaris, M Lecanda, F Solis, M Ezquer… - PloS one, 2013 - journals.plos.org
Background/Aim Hypercaloric diet ingestion and sedentary lifestyle result in obesity.
Metabolic syndrome is a cluster of clinical features secondary to obesity, considered as a …
Metabolic syndrome is a cluster of clinical features secondary to obesity, considered as a …
Identification of placental nutrient transporters associated with intrauterine growth restriction and pre-eclampsia
X Huang, P Anderle, L Hostettler, MU Baumann… - BMC genomics, 2018 - Springer
Background Gestational disorders such as intrauterine growth restriction (IUGR) and pre-
eclampsia (PE) are main causes of poor perinatal outcomes worldwide. Both diseases are …
eclampsia (PE) are main causes of poor perinatal outcomes worldwide. Both diseases are …
Maternal hypercholesterolemia in pregnancy associates with umbilical vein endothelial dysfunction: role of endothelial nitric oxide synthase and arginase II
Objective—Human pregnancy that courses with maternal supraphysiological
hypercholesterolemia (MSPH) correlates with atherosclerotic lesions in fetal arteries. It is …
hypercholesterolemia (MSPH) correlates with atherosclerotic lesions in fetal arteries. It is …
Loss of brain energy metabolism control as a driver for memory impairment upon insulin resistance
JMN Duarte - Biochemical Society Transactions, 2023 - portlandpress.com
The pathophysiological mechanisms intersecting metabolic and neurodegenerative
disorders include insulin resistance, which has a strong involvement of environmental …
disorders include insulin resistance, which has a strong involvement of environmental …
Adenosine and preeclampsia
Adenosine is an endogenous nucleoside with pleiotropic effects in different physiological
processes including circulation, renal blood flow, immune function, or glucose homeostasis …
processes including circulation, renal blood flow, immune function, or glucose homeostasis …
Insulin reverses D-glucose–increased nitric oxide and reactive oxygen species generation in human umbilical vein endothelial cells
M González, S Rojas, P Avila, L Cabrera, R Villalobos… - PloS one, 2015 - journals.plos.org
Vascular tone is controlled by the L-arginine/nitric oxide (NO) pathway, and NO
bioavailability is strongly affected by hyperglycaemia-induced oxidative stress. Insulin leads …
bioavailability is strongly affected by hyperglycaemia-induced oxidative stress. Insulin leads …
Insulin requires normal expression and signaling of insulin receptor A to reverse gestational diabetes-reduced adenosine transport in human umbilical vein …
Reduced adenosine uptake via human equilibrative nucleoside transporter 1 (hENT1) in
human umbilical vein endothelial cells (HUVECs) from gestational diabetes mellitus (GDM) …
human umbilical vein endothelial cells (HUVECs) from gestational diabetes mellitus (GDM) …
Nitric oxide is a central common metabolite in vascular dysfunction associated with diseases of human pregnancy
Preeclampsia (PE), gestational diabetes mellitus (GDM), and maternal supraphysiological
hypercholesterolaemia (MSPH) are pregnancy-related conditions that cause metabolic …
hypercholesterolaemia (MSPH) are pregnancy-related conditions that cause metabolic …