Orexins, also known as hypocretins, are two neuropeptides secreted from orexin-containing
neurons, mainly in the lateral hypothalamus (LH). Orexins orchestrate their effects by …

Orexins (also known as hypocretins) are neuropeptides located exclusively in hypothalamic
neurons that have extensive projections throughout the central nervous system and bind two …

The discovery of hypocretins (orexins) and their causal implication in narcolepsy is the most
important advance in sleep research and sleep medicine since the discovery of rapid eye …

Orexins/hypocretins are hypothalamic peptides involved in arousal and wakefulness, but
also play a critical role in drug addiction and reward-related behaviors. Here, we review the …

The neuropeptides orexins are important in regulating the neurobiological systems that
respond to stressful stimuli. Furthermore, orexins are known to play a role many of the …

The associations between depressive symptoms and hypersomnia are complex and often
bidirectional. Of the many disorders associated with excessive sleepiness in the general …

Orexin signaling is essential for normal regulation of arousal and behavioral state control
and represents an attractive target for therapeutics combating insomnia. Alternatively termed …

Orexins (hypocretins) are critically involved in coordinating appropriate physiological and
behavioral responses to aversive and threatening stimuli. Acute stressors engage orexin …

Historically, pharmacological therapies have used mechanisms such as γ-aminobutyric acid
A (GABAA) receptor potentiation to drive sleep through broad suppression of central …

Peptides derived from pre-proglucagon (GCG peptides) act in both the periphery and the
CNS to change food intake, glucose homeostasis, and metabolic rate while playing a role in …